Basal cell carcinoma causes: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 21: | Line 21: | ||
|- | |- | ||
| '''Gene mutations'''||TP53 gene mutations and the inappropriate activation of the hedgehog signaling pathway (loss-of-function mutations in tumor-suppressor protein patched homologue 1 (PTCH1) and gain-of-function mutations in sonic hedgehog (SHH), smoothened (SMO), and Gli) are associated with basal cell carcinoma | | '''Gene mutations'''||TP53 gene mutations and the inappropriate activation of the hedgehog signaling pathway (loss-of-function mutations in tumor-suppressor protein patched homologue 1 (PTCH1) and gain-of-function mutations in sonic hedgehog (SHH), smoothened (SMO), and Gli) are associated with basal cell carcinoma<ref name="pmid20546211">{{cite journal| author=de Zwaan SE, Haass NK| title=Genetics of basal cell carcinoma. | journal=Australas J Dermatol | year= 2010 | volume= 51 | issue= 2 | pages= 81-92; quiz 93-4 | pmid=20546211 | doi=10.1111/j.1440-0960.2009.00579.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20546211 }} </ref> | ||
|- | |- | ||
| '''Physical features'''||Red/blonde hair; blue/green eyes; freckling; fair complexion (particularly if related to albinism)<ref name="LearSmith1997">{{cite journal|last1=Lear|first1=J. T.|last2=Smith|first2=A. G.|title=Basal cell carcinoma.|journal=Postgraduate Medical Journal|volume=73|issue=863|year=1997|pages=538–542|issn=0032-5473|doi=10.1136/pgmj.73.863.538}}</ref> | |||
| ''' | |- | ||
| '''Gender'''||The male gender has a higher risk for basal cell carcinoma<ref name="LearSmith1997">{{cite journal|last1=Lear|first1=J. T.|last2=Smith|first2=A. G.|title=Basal cell carcinoma.|journal=Postgraduate Medical Journal|volume=73|issue=863|year=1997|pages=538–542|issn=0032-5473|doi=10.1136/pgmj.73.863.538}}</ref> | |||
|- | |- | ||
| '''Epidermodysplastic verruciformis'''||Epidermodysplastic verruciformis is an autosomal recessive disorder characterized by the development of basal cell carcinoma and squamous cell carcinoma from warts (human papillomavirus infection) | | '''Xeroderma pigmentosum'''||This an autosomal recessive disorder; it results in the inability to repair ultraviolet-induced DNA damage; pigmentary changes are seen early in life, followed by the development of basal cell carcinoma, squamous cell carcinoma, and malignant melanoma; other features include corneal opacities, eventual blindness, and neurological deficits<ref name="LearSmith1997">{{cite journal|last1=Lear|first1=J. T.|last2=Smith|first2=A. G.|title=Basal cell carcinoma.|journal=Postgraduate Medical Journal|volume=73|issue=863|year=1997|pages=538–542|issn=0032-5473|doi=10.1136/pgmj.73.863.538}}</ref> | ||
|- | |||
| '''Epidermodysplastic verruciformis'''||Epidermodysplastic verruciformis is an autosomal recessive disorder characterized by the development of basal cell carcinoma and squamous cell carcinoma from warts (human papillomavirus infection)<ref name="pmid15149508">{{cite journal| author=Harwood CA, Surentheran T, Sasieni P, Proby CM, Bordea C, Leigh IM et al.| title=Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin. | journal=Br J Dermatol | year= 2004 | volume= 150 | issue= 5 | pages= 949-57 | pmid=15149508 | doi=10.1111/j.1365-2133.2004.05847.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15149508 }} </ref> | |||
|- | |- | ||
| Line 44: | Line 50: | ||
|} | |} | ||
==References== | ==References== | ||
Revision as of 14:50, 27 July 2015
|
Basal cell carcinoma Microchapters |
|
Diagnosis |
|---|
|
Case Studies |
|
Basal cell carcinoma causes On the Web |
|
American Roentgen Ray Society Images of Basal cell carcinoma causes |
|
Risk calculators and risk factors for Basal cell carcinoma causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Saarah T. Alkhairy, M.D.
Overview
There are many causes associated with basal cell carcinoma such as sunlight, gene mutations, and other conditions, for example, xeroderma pigmentosum.
Basal Cell Carcinoma Causes
Although the exact cause is unknown, there are some environmental and genetic factor that may predispose to basal cell carcinoma.
The following table summarizes the risk factors of basal cell carcinoma (BCC):
| Risk Factor | Description |
| Radiation exposure | Sunlight (UV light), tanning beds, and x-rays exposure are associated with basal cell carcinoma formation[1] |
| Gene mutations | TP53 gene mutations and the inappropriate activation of the hedgehog signaling pathway (loss-of-function mutations in tumor-suppressor protein patched homologue 1 (PTCH1) and gain-of-function mutations in sonic hedgehog (SHH), smoothened (SMO), and Gli) are associated with basal cell carcinoma[2] |
| Physical features | Red/blonde hair; blue/green eyes; freckling; fair complexion (particularly if related to albinism)[3] |
| Gender | The male gender has a higher risk for basal cell carcinoma[3] |
| Xeroderma pigmentosum | This an autosomal recessive disorder; it results in the inability to repair ultraviolet-induced DNA damage; pigmentary changes are seen early in life, followed by the development of basal cell carcinoma, squamous cell carcinoma, and malignant melanoma; other features include corneal opacities, eventual blindness, and neurological deficits[3] |
| Epidermodysplastic verruciformis | Epidermodysplastic verruciformis is an autosomal recessive disorder characterized by the development of basal cell carcinoma and squamous cell carcinoma from warts (human papillomavirus infection)[4] |
| Nevoid basal cell carcinoma syndrome | This is an autosomal dominant disorder that can result in basal cell carcinomas, multiple odontogenic keratocysts, palmoplantar pitting, intracranial calcification, and rib anomalies[5] |
| Bazex Syndrome | The features of Bazex syndrome include follicular atrophoderma, multiple basal cell carcinomas, and local anhidrosis[6] |
| Rombo syndrome | Rombo syndrome is an autosomal dominant condition distinguished by basal cell carcinoma and atrophoderma vermiculatum, trichoepitheliomas, hypotrichosis milia, and peripheral vasodilation with cyanosis[7] |
References
- ↑ Lim JL, Stern RS (2005). "High levels of ultraviolet B exposure increase the risk of non-melanoma skin cancer in psoralen and ultraviolet A-treated patients". J Invest Dermatol. 124 (3): 505–13. doi:10.1111/j.0022-202X.2005.23618.x. PMID 15737190.
- ↑ de Zwaan SE, Haass NK (2010). "Genetics of basal cell carcinoma". Australas J Dermatol. 51 (2): 81–92, quiz 93-4. doi:10.1111/j.1440-0960.2009.00579.x. PMID 20546211.
- ↑ 3.0 3.1 3.2 Lear, J. T.; Smith, A. G. (1997). "Basal cell carcinoma". Postgraduate Medical Journal. 73 (863): 538–542. doi:10.1136/pgmj.73.863.538. ISSN 0032-5473.
- ↑ Harwood CA, Surentheran T, Sasieni P, Proby CM, Bordea C, Leigh IM; et al. (2004). "Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin". Br J Dermatol. 150 (5): 949–57. doi:10.1111/j.1365-2133.2004.05847.x. PMID 15149508.
- ↑ Cohen MM (1999). "Nevoid basal cell carcinoma syndrome: molecular biology and new hypotheses". Int J Oral Maxillofac Surg. 28 (3): 216–23. PMID 10355946.
- ↑ Centers for Disease Control and Prevention (CDC). Sunburn prevalence among adults--United States, 1999, 2003, and 2004. MMWR Morb Mortal Wkly Rep. 2007 Jun 1. 56(21):524-8
- ↑ Michaëlsson G, Olsson E, Westermark P (1981). "The Rombo syndrome: a familial disorder with vermiculate atrophoderma, milia, hypotrichosis, trichoepitheliomas, basal cell carcinomas and peripheral vasodilation with cyanosis". Acta Derm Venereol. 61 (6): 497–503. PMID 6177160.