Campylobacteriosis pathophysiology: Difference between revisions
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Campylobacter organisms are curved or spiral, motile, non–spore-forming, [[gram-negative]] rods. The known routes of transmission are fecal-oral, person-to-person sexual contact, raw [[milk]] and [[poultry]] ingestion, and waterborne (ie, through contaminated water supplies). Exposure to sick pets, especially puppies, has also been associated with outbreaks. | Campylobacter organisms are curved or spiral, motile, non–spore-forming, [[gram-negative]] rods. The known routes of transmission are fecal-oral, person-to-person sexual contact, raw [[milk]] and [[poultry]] ingestion, and waterborne (ie, through contaminated water supplies). Exposure to sick pets, especially puppies, has also been associated with outbreaks. | ||
==Pathophysiology== | ==Pathophysiology== | ||
* Campylobacter organisms are curved or spiral, motile, non–spore-forming, [[gram-negative]] rods. | |||
* C jejuni appears to invade and destroy [[epithelial cells]]. Some strains of C jejuni produce a [[cholera]]-like enterotoxin, which is important in the watery [[diarrhea]] observed in infections. | |||
* The [[organism]] produces diffuse, bloody, edematous, and exudative [[enteritis]]. In a small number of cases, the infection may be associated with [[hemolytic uremic syndrome]] and [[thrombotic thrombocytopenic purpura]] through a poorly understood mechanism. | |||
* In patients with [[HIV]], [[infections]] may be more frequent, may cause prolonged or recurrent diarrhea, and may be more commonly associated with bacteremia and antibiotic resistance. T | |||
* The severity and persistence of [[infection]] in patients with [[AIDS]] and [[hypogammaglobulinemia]] indicates that both cell-mediated and humoral immunity are important in preventing and terminating infection. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
Revision as of 16:28, 8 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Campylobacter organisms are curved or spiral, motile, non–spore-forming, gram-negative rods. The known routes of transmission are fecal-oral, person-to-person sexual contact, raw milk and poultry ingestion, and waterborne (ie, through contaminated water supplies). Exposure to sick pets, especially puppies, has also been associated with outbreaks.
Pathophysiology
- Campylobacter organisms are curved or spiral, motile, non–spore-forming, gram-negative rods.
- C jejuni appears to invade and destroy epithelial cells. Some strains of C jejuni produce a cholera-like enterotoxin, which is important in the watery diarrhea observed in infections.
- The organism produces diffuse, bloody, edematous, and exudative enteritis. In a small number of cases, the infection may be associated with hemolytic uremic syndrome and thrombotic thrombocytopenic purpura through a poorly understood mechanism.
- In patients with HIV, infections may be more frequent, may cause prolonged or recurrent diarrhea, and may be more commonly associated with bacteremia and antibiotic resistance. T
- The severity and persistence of infection in patients with AIDS and hypogammaglobulinemia indicates that both cell-mediated and humoral immunity are important in preventing and terminating infection.