Marburg hemorrhagic fever pathophysiology: Difference between revisions
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{{Marburg hemorrhagic fever}} | {{Marburg hemorrhagic fever}} | ||
{{ | ==Pathophysiology== | ||
===Pathogen=== | |||
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| [[File:Marburg Hemorrhagic Virus.png|200px|thumb|none| Electron micrograph (TEM) of the Marburg Hemorrhagic Virus (MHV) .<SMALL> ''Image provided by the CDC [http://phil.cdc.gov/phil/details.asp Centers for Disease Control and Prevention] ''<ref>{{Cite web | title = http://phil.cdc.gov/phil/details.asp | url = http://phil.cdc.gov/phil/details.asp}}</ref></SMALL>]] | |||
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*[[Marburg virus]] is the causative agent of Marburg haemorrhagic fever (MHF). Marburg and [[Ebola]] viruses are the two members of the [[Filoviridae]] family ([[filovirus]]). Though caused by different viruses, the two diseases are clinically similar. | |||
*The viral structure is typical of [[filovirus]]es, with long threadlike particles which have a consistent diameter but vary greatly in length from an average of 800 [[nanometer]]s up to 14,000 nm. Peak infectious activity is at approximately 790 nm. | |||
*''[[Virion]]s'' contain seven known structural [[protein]]s. Four proteins form the nucelocapsid of the Marburg virus: NP, VP35, VP30, and L.<ref name="pmid9791031">{{cite journal| author=Becker S, Rinne C, Hofsäss U, Klenk HD, Mühlberger E| title=Interactions of Marburg virus nucleocapsid proteins. | journal=Virology | year= 1998 | volume= 249 | issue= 2 | pages= 406-17 | pmid=9791031 | doi=10.1006/viro.1998.9328 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9791031 }} </ref> While nearly identical to [[Ebola]] virus in structure, Marburg virus is [[antigen]]ically distinct from Ebola virus. | |||
*Marburg virus was the first [[filovirus]] to be identified. | |||
===Transmission=== | |||
*Initial human infection results from prolonged exposure to mines or caves inhabited by Rousettus bat colonies. The reservoir host of Marburg virus is the African fruit bat, ''Rousettus aegyptiacus''. Primates (including humans) can become infected with Marburg virus, and may develop serious disease with high mortality. | |||
*Transmission is mainly human-to-human, resulting from close contact with the [[blood]], [[secretions]], [[organs]] or other bodily [[fluids]] of infected persons.<ref name="pmid11988060">{{cite journal| author=Borio L, Inglesby T, Peters CJ, Schmaljohn AL, Hughes JM, Jahrling PB et al.| title=Hemorrhagic fever viruses as biological weapons: medical and public health management. | journal=JAMA | year= 2002 | volume= 287 | issue= 18 | pages= 2391-405 | pmid=11988060 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11988060 }} </ref> | |||
*Transmission via infected semen can occur up to seven weeks after clinical recovery. | |||
*Transmission to health-care workers has been reported while treating Marburg patients, mainly due to incorrect or inadequate use of personal protective equipment. | |||
==References== | ==References== | ||
Revision as of 16:11, 10 August 2015
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Pathophysiology
Pathogen
 |
- Marburg virus is the causative agent of Marburg haemorrhagic fever (MHF). Marburg and Ebola viruses are the two members of the Filoviridae family (filovirus). Though caused by different viruses, the two diseases are clinically similar.
- The viral structure is typical of filoviruses, with long threadlike particles which have a consistent diameter but vary greatly in length from an average of 800 nanometers up to 14,000 nm. Peak infectious activity is at approximately 790 nm.
- Virions contain seven known structural proteins. Four proteins form the nucelocapsid of the Marburg virus: NP, VP35, VP30, and L.[2] While nearly identical to Ebola virus in structure, Marburg virus is antigenically distinct from Ebola virus.
- Marburg virus was the first filovirus to be identified.
Transmission
- Initial human infection results from prolonged exposure to mines or caves inhabited by Rousettus bat colonies. The reservoir host of Marburg virus is the African fruit bat, Rousettus aegyptiacus. Primates (including humans) can become infected with Marburg virus, and may develop serious disease with high mortality.
- Transmission is mainly human-to-human, resulting from close contact with the blood, secretions, organs or other bodily fluids of infected persons.[3]
- Transmission via infected semen can occur up to seven weeks after clinical recovery.
- Transmission to health-care workers has been reported while treating Marburg patients, mainly due to incorrect or inadequate use of personal protective equipment.
References
- ↑ "http://phil.cdc.gov/phil/details.asp". External link in
|title=(help) - ↑ Becker S, Rinne C, Hofsäss U, Klenk HD, Mühlberger E (1998). "Interactions of Marburg virus nucleocapsid proteins". Virology. 249 (2): 406–17. doi:10.1006/viro.1998.9328. PMID 9791031.
- ↑ Borio L, Inglesby T, Peters CJ, Schmaljohn AL, Hughes JM, Jahrling PB; et al. (2002). "Hemorrhagic fever viruses as biological weapons: medical and public health management". JAMA. 287 (18): 2391–405. PMID 11988060.