|
|
| Line 1: |
Line 1: |
| __notoc__
| | ==heading1== |
| ==Aspergillosis== | |
| ===Invasive pulmonary aspergillosis===
| |
| :*Preferred regimen: [[Voriconazole]] (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
| |
| :*Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV {{or}} [[Amphotericin B]] lipid complex (ABLC) 5 mg/ kg/day IV {{or}} [[Caspofungin]] (70 mg day 1 IV and 50 mg/day IV thereafter) {{or}} [[Micafungin]] (IV 100–150 mg/day; dose not established ), [[Posaconazole]] (200 mg QID initially, then 400 mg BID PO after stabilization of disease ){{or}} [[Itraconazole]] (dosage depends upon formulation)
| |
| | |
| ===Invasive sinus aspergillosis===
| |
| :*Preferred regimen: [[Voriconazole]] (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
| |
| :*Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV {{or}} [[Amphotericin B]] lipid complex (ABLC) 5 mg/ kg/day IV {{or}} [[Caspofungin]] (70 mg day 1 IV and 50 mg/day IV thereafter) {{or}} [[Micafungin]] (IV 100–150 mg/day; dose not established ), [[Posaconazole]] (200 mg QID initially, then 400 mg BID PO after stabilization of disease ){{or}} [[Itraconazole]] (dosage depends upon formulation)
| |
| | |
| ===Tracheobronchial aspergillosis===
| |
| :*Preferred regimen: [[Voriconazole]] (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
| |
| :*Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV {{or}} [[Amphotericin B]] lipid complex (ABLC) 5 mg/ kg/day IV {{or}} [[Caspofungin]] (70 mg day 1 IV and 50 mg/day IV thereafter) {{or}} [[Micafungin]] (IV 100–150 mg/day; dose not established ), [[Posaconazole]] (200 mg QID initially, then 400 mg BID PO after stabilization of disease ){{or}} [[Itraconazole]] (dosage depends upon formulation)
| |
| | |
| ===Chronic necrotizing pulmonary aspergillosis===
| |
| :*Preferred regimen: [[Voriconazole]] (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
| |
| :*Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV {{or}} [[Amphotericin B]] lipid complex (ABLC) 5 mg/ kg/day IV {{or}} [[Caspofungin]] (70 mg day 1 IV and 50 mg/day IV thereafter) {{or}} [[Micafungin]] (IV 100–150 mg/day; dose not established ), [[Posaconazole]] (200 mg QID initially, then 400 mg BID PO after stabilization of disease ){{or}} [[Itraconazole]] (dosage depends upon formulation)
| |
| | |
| ===Aspergillosis of the CNS===
| |
| :*Preferred regimen: [[Voriconazole]] (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
| |
| :*Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV {{or}} [[Amphotericin B]] lipid complex (ABLC) 5 mg/ kg/day IV {{or}} [[Caspofungin]] (70 mg day 1 IV and 50 mg/day IV thereafter) {{or}} [[Micafungin]] (IV 100–150 mg/day; dose not established ), [[Posaconazole]] (200 mg QID initially, then 400 mg BID PO after stabilization of disease ){{or}} [[Itraconazole]] (dosage depends upon formulation)
| |
| ===Aspergillus infections of the heart (endocarditis, pericarditis, and myocarditis)===
| |
| | |
| ===Aspergillus osteomyelitis and septic arthritis===
| |
| | |
| ===Aspergillus infections of the eye (endophthalmitis and keratitis)===
| |
| | |
| ===Cutaneous aspergillosis===
| |