Leptospirosis medical therapy: Difference between revisions
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Shanshan Cen (talk | contribs) (Created page with "__NOTOC__ {{Leptospirosis}} {{CMG}} ==Treatment== Leptospirosis treatment is a relatively complicated process comprising two main components - suppressing the causative ag...") |
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==Treatment== | ==Treatment== | ||
Antimicrobial therapy is the mainstay of therapy for Leptospirosis. Less severe cases can be treated with either [[Amoxicillin]], [[Ampicillin]], [[Doxycycline]], or [[Erythromycin]]. | |||
Severe cases may be treated with high doses of intravenous [[Penicillin]]. Supportive therapy measures (esp. in severe cases) include [[detoxication]] and normalization of the [[Electrolyte#Physiological importance|hydro-electrolytic balance]]. Glucose and salt solution infusions may be administered; [[dialysis]] is used in serious cases. | |||
Supportive therapy measures (esp. in severe cases) include [[detoxication]] and normalization of the [[Electrolyte#Physiological importance|hydro-electrolytic balance]]. Glucose and salt solution infusions may be administered; [[dialysis]] is used in serious cases | |||
===Antimicrobial regimen=== | ===Antimicrobial regimen=== | ||
*1. '''Severe''' <ref>{{cite book | last = LastName | first = FirstName | title = Human leptospirosis guidance for diagnosis, surveillance and control | publisher = World Health Organization | location = Geneva | year = 2003 | isbn = 9241545895 | *1. '''Severe''' <ref>{{cite book | last = LastName | first = FirstName | title = Human leptospirosis guidance for diagnosis, surveillance and control | publisher = World Health Organization | location = Geneva | year = 2003 | isbn = 9241545895 }}</ref> | ||
:* | :* High doses of [[Penicillin]] IV | ||
*2. '''Less severe''' | *2. '''Less severe''' | ||
:* Preferred regimen | :* Preferred regimen: [[Amoxycillin]] {{or}} [[Ampicillin]] {{or}} [[Doxycycline]] {{or}} [[Erythromycin]] | ||
:* Alternative regimen: [[Ceftriaxone]] {{or}} [[Cefotaxime]] {{or}} [[Quinolone]] | |||
:* Note (1): Treatment with effective antibiotics should be initiated as soon as the diagnosis of leptospirosis is suspected and preferably before the fifth day after the onset of illness | |||
:* Note (2): Clinicians should never wait for the results of laboratory tests before starting treatment with antibiotics because serological tests do not become positive until about a week after the onset of illness, and cultures may not become positive for several weeks. | |||
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==References== | ==References== | ||
Revision as of 14:27, 12 August 2015
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Leptospirosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Leptospirosis medical therapy On the Web |
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American Roentgen Ray Society Images of Leptospirosis medical therapy |
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Risk calculators and risk factors for Leptospirosis medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Treatment
Antimicrobial therapy is the mainstay of therapy for Leptospirosis. Less severe cases can be treated with either Amoxicillin, Ampicillin, Doxycycline, or Erythromycin. Severe cases may be treated with high doses of intravenous Penicillin. Supportive therapy measures (esp. in severe cases) include detoxication and normalization of the hydro-electrolytic balance. Glucose and salt solution infusions may be administered; dialysis is used in serious cases.
Antimicrobial regimen
- 1. Severe [1]
- High doses of Penicillin IV
- 2. Less severe
- Preferred regimen: Amoxycillin OR Ampicillin OR Doxycycline OR Erythromycin
- Alternative regimen: Ceftriaxone OR Cefotaxime OR Quinolone
- Note (1): Treatment with effective antibiotics should be initiated as soon as the diagnosis of leptospirosis is suspected and preferably before the fifth day after the onset of illness
- Note (2): Clinicians should never wait for the results of laboratory tests before starting treatment with antibiotics because serological tests do not become positive until about a week after the onset of illness, and cultures may not become positive for several weeks.
References
- ↑ LastName, FirstName (2003). Human leptospirosis guidance for diagnosis, surveillance and control. Geneva: World Health Organization. ISBN 9241545895.