Actinomycosis medical therapy: Difference between revisions
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{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
Treatment for actinomycosis consists of antibiotics such as | Treatment for actinomycosis consists of antibiotics such as penicillin for six to twelve months, as well as surgery if the disease is extensive. | ||
===Antimicrobial regimen=== | ===Antimicrobial regimen=== | ||
*'''Actinomyces species including A. israeli'''<ref>{{cite book | last = Bennett | first = John | title = Mandell, Douglas, and Bennett's principles and practice of infectious diseases | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2015 | isbn = 978-1455748013 }}</ref> | * 1. '''Actinomyces species including A. israeli'''<ref>{{cite book | last = Bennett | first = John | title = Mandell, Douglas, and Bennett's principles and practice of infectious diseases | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2015 | isbn = 978-1455748013 }}</ref> | ||
:*Preferred regimen: [[Penicillin]] 3-4 MU IV q4h for 2-6 weeks {{then}} [[Penicillin V]] 2-4 g/day PO qid for 6-12 months | :*Preferred regimen: [[Penicillin]] 3-4 MU IV q4h for 2-6 weeks {{then}} [[Penicillin V]] 2-4 g/day PO qid for 6-12 months | ||
:*Alternative regimen (1): [[Erythromycin]] 500-1000 mg IV q6h {{or}} 500 mg PO qid | :*Alternative regimen (1): [[Erythromycin]] 500-1000 mg IV q6h {{or}} 500 mg PO qid | ||
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:*Alternative regimen (4): [[Clindamycin]] 900 mg IV q8h {{or}} 300-450 mg PO qd | :*Alternative regimen (4): [[Clindamycin]] 900 mg IV q8h {{or}} 300-450 mg PO qd | ||
:*Alternative regimen (5): [[Minocycline]] 100 mg IV q12h {{or}} 100 mg PO bid | :*Alternative regimen (5): [[Minocycline]] 100 mg IV q12h {{or}} 100 mg PO bid | ||
*2. '''Cervico-facial actinomycosis'''<ref name="pmid21990282">{{cite journal| author=Wong VK, Turmezei TD, Weston VC| title=Actinomycosis. | journal=BMJ | year= 2011 | volume= 343 | issue= | pages= d6099 | pmid=21990282 | doi=10.1136/bmj.d6099 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21990282 }} </ref> | |||
:*Preferred regimen: [[Ampicillin]] 50 mg/kg/day IV q8h (4-6 weeks) <u>'''THEN'''</u> [[Penicillin V]] 2-4 g/day PO q6h (3-6 months) | |||
:*Alternative regimen: [[Penicillin G]] 10-20 MU/day IV q6h (4-6 weeks) <u>'''THEN'''</u> [[Penicillin V]] 2-4 g/day PO q6h (3-6 months) | |||
:*Note: In patients allergic to [[Penicillin]], consider [[Doxycycline]], [[Clindamycin]], or [[Erythromycin]]. | |||
==References== | ==References== | ||
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[[Category:Overview complete]] | [[Category:Overview complete]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category: Infectious Disease Project]] | |||
Revision as of 10:49, 13 August 2015
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Risk calculators and risk factors for Actinomycosis medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Treatment for actinomycosis consists of antibiotics such as penicillin for six to twelve months, as well as surgery if the disease is extensive.
Antimicrobial regimen
- 1. Actinomyces species including A. israeli[1]
- Preferred regimen: Penicillin 3-4 MU IV q4h for 2-6 weeks THEN Penicillin V 2-4 g/day PO qid for 6-12 months
- Alternative regimen (1): Erythromycin 500-1000 mg IV q6h OR 500 mg PO qid
- Alternative regimen (2): Tetracyclin 500 mg PO qid
- Alternative regimen (3): Doxycycline 100 mg IV q12h OR 100 mg PO bid
- Alternative regimen (4): Clindamycin 900 mg IV q8h OR 300-450 mg PO qd
- Alternative regimen (5): Minocycline 100 mg IV q12h OR 100 mg PO bid
- 2. Cervico-facial actinomycosis[2]
- Preferred regimen: Ampicillin 50 mg/kg/day IV q8h (4-6 weeks) THEN Penicillin V 2-4 g/day PO q6h (3-6 months)
- Alternative regimen: Penicillin G 10-20 MU/day IV q6h (4-6 weeks) THEN Penicillin V 2-4 g/day PO q6h (3-6 months)
- Note: In patients allergic to Penicillin, consider Doxycycline, Clindamycin, or Erythromycin.
References
- ↑ Bennett, John (2015). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1455748013.
- ↑ Wong VK, Turmezei TD, Weston VC (2011). "Actinomycosis". BMJ. 343: d6099. doi:10.1136/bmj.d6099. PMID 21990282.
de:Aktinomykose gl:Actinomicose hr:Aktinomikoza nl:Actinomycose sr:Актиномикоза fi:Aktinomykoosi uk:Актиномікоз