Dermatofibroma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Shivali Marketkar, M.B.B.S. [2]

Pathophysiology

• Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.
• Dermatofibromas are composed of disordered collagen laid down by fibroblasts.

Immunohistochemical staining

Neoplasm	CD34	Stromelysin-3	Factor XIIIa
Dermatofibroma	+	+	+
Dermatofibrosarcoma protuberans	+	-	-

Video

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