Palmar plantar erythrodysesthesia differential diagnosis: Difference between revisions
Created page with "{{Palmar plantar erythrodysesthesia}} {{CMG}} ==Overview== '''Palmar plantar erythrodysesthesia''' (PPE) is a swelling and numbness of the hands and feet that occurs with [[ch..." |
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==Overview== | ==Overview== | ||
==Differential diagnosis== | ==Differential diagnosis== | ||
The problem arises in patients after [[bone marrow transplant|bone marrow transplants]], as the clinical and histologic features of PPE can be similar to cutaneous manifestations of acute (first 3 weeks) [[graft-versus-host disease]]. It is important to differentiate PPE, which is benign, from the more dangerous graft-versus-host disease. As time progresses, patients with graft-versus-host disease progress to have other body parts affected, while PPE is limited to hands and feet. Serial biopsies every 3 to 5 days can also be helpful in differentiating the two disorders (Crider et al, 1986). | The problem arises in patients after [[bone marrow transplant|bone marrow transplants]], as the clinical and histologic features of PPE can be similar to cutaneous manifestations of acute (first 3 weeks) [[graft-versus-host disease]]. It is important to differentiate PPE, which is benign, from the more dangerous graft-versus-host disease. As time progresses, patients with graft-versus-host disease progress to have other body parts affected, while PPE is limited to hands and feet. Serial biopsies every 3 to 5 days can also be helpful in differentiating the two disorders (Crider et al, 1986). | ||
Revision as of 15:01, 17 August 2015
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Differentiating Palmar plantar erythrodysesthesia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Differential diagnosis
The problem arises in patients after bone marrow transplants, as the clinical and histologic features of PPE can be similar to cutaneous manifestations of acute (first 3 weeks) graft-versus-host disease. It is important to differentiate PPE, which is benign, from the more dangerous graft-versus-host disease. As time progresses, patients with graft-versus-host disease progress to have other body parts affected, while PPE is limited to hands and feet. Serial biopsies every 3 to 5 days can also be helpful in differentiating the two disorders (Crider et al, 1986).