Actinomycosis medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
Antimicrobial therapy is indicated in actinomycosis. For cervico-facial actinomycosis, [[Ampicillin]] is administered followed by [[Penicillin V]]. Patients with more extensive disease may require surgery. | |||
===Antimicrobial regimen=== | ===Antimicrobial regimen=== | ||
Revision as of 17:18, 17 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Antimicrobial therapy is indicated in actinomycosis. For cervico-facial actinomycosis, Ampicillin is administered followed by Penicillin V. Patients with more extensive disease may require surgery.
Antimicrobial regimen
- 1. Actinomyces species including A. israeli[1]
- Preferred regimen: Penicillin 3-4 MU IV q4h for 2-6 weeks THEN Penicillin V 2-4 g/day PO qid for 6-12 months
- Alternative regimen (1): Erythromycin 500-1000 mg IV q6h OR 500 mg PO qid
- Alternative regimen (2): Tetracyclin 500 mg PO qid
- Alternative regimen (3): Doxycycline 100 mg IV q12h OR 100 mg PO bid
- Alternative regimen (4): Clindamycin 900 mg IV q8h OR 300-450 mg PO qd
- Alternative regimen (5): Minocycline 100 mg IV q12h OR 100 mg PO bid
- 2. Cervico-facial actinomycosis[2]
- Preferred regimen: Ampicillin 50 mg/kg/day IV q8h (4-6 weeks) THEN Penicillin V 2-4 g/day PO q6h (3-6 months)
- Alternative regimen: Penicillin G 10-20 MU/day IV q6h (4-6 weeks) THEN Penicillin V 2-4 g/day PO q6h (3-6 months)
- Note: In patients allergic to Penicillin, consider Doxycycline, Clindamycin, or Erythromycin.
References
- ↑ Bennett, John (2015). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1455748013.
- ↑ Wong VK, Turmezei TD, Weston VC (2011). "Actinomycosis". BMJ. 343: d6099. doi:10.1136/bmj.d6099. PMID 21990282.
de:Aktinomykose gl:Actinomicose hr:Aktinomikoza nl:Actinomycose sr:Актиномикоза fi:Aktinomykoosi uk:Актиномікоз