Pancreatitis pathophysiology: Difference between revisions
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Pancreatic diseases are notoriously complex disorders resulting from the interaction of multiple genetic, environmental and metabolic factors. Three candidates for genetic testing are currently under investigation: Trypsinogen mutations, Cystic Fibrosis Transmembrane Conductance Regulator Gene (''CFTR'') mutations and ''SPINK1'' which codes for PSTI - a specific trypsin inhibitor.<ref> {{cite web | author=D. Whitcomb|year=2006 | title=Genetic Testing for Pancreatitis|url=http://www.touchalimentarydisease.com/articles.cfm?article_id=6374&level=2}}</ref> | Pancreatic diseases are notoriously complex disorders resulting from the interaction of multiple genetic, environmental and metabolic factors. Three candidates for genetic testing are currently under investigation: Trypsinogen mutations, Cystic Fibrosis Transmembrane Conductance Regulator Gene (''CFTR'') mutations and ''SPINK1'' which codes for PSTI - a specific trypsin inhibitor.<ref> {{cite web | author=D. Whitcomb|year=2006 | title=Genetic Testing for Pancreatitis|url=http://www.touchalimentarydisease.com/articles.cfm?article_id=6374&level=2}}</ref> | ||
==References== | ==References== | ||
{{reflist|2}} | |||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
[[Category:Inflammations]] | [[Category:Inflammations]] |
Revision as of 13:35, 18 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
Genetics
Hereditary pancreatitis may be due to a genetic abnormality that renders trypsinogen active within the pancreas, which in turn leads to digestion of the pancreas from the inside.
Pancreatic diseases are notoriously complex disorders resulting from the interaction of multiple genetic, environmental and metabolic factors. Three candidates for genetic testing are currently under investigation: Trypsinogen mutations, Cystic Fibrosis Transmembrane Conductance Regulator Gene (CFTR) mutations and SPINK1 which codes for PSTI - a specific trypsin inhibitor.[1]
References
- ↑ D. Whitcomb (2006). "Genetic Testing for Pancreatitis".