Denaverine: Difference between revisions

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Denaverine
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy; category	Gr 1 (Germany);
Routes of; administration	intramuscular injection, suppositories
ATCvet code	Template:Infobox drug/formatATCvet; Template:Infobox drug/formatATCvet;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	8% (suppositories),; 37% (oral solution)
Metabolism	mainly hepatic, at least 11 metabolites
Elimination half-life	34 hours
Identifiers
	IUPAC name 2-(Dimethylamino)ethyl (2-ethylbutoxy)diphenylacetate;
CAS Number	3579-62-2 ; 3321-06-0 (hydrochloride);
PubChem CID	71130;
ChemSpider	64278 ;
UNII	O14NF38MTL;
KEGG	D07787 ;
ChEMBL	ChEMBL1614656 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C24H33NO3
Molar mass	383.52 g/mol
3D model (JSmol)	Interactive image;
	SMILES CCC(CC)COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(C)C;
	InChI InChI=1S/C24H33NO3/c1-5-20(6-2)19-28-24(21-13-9-7-10-14-21,22-15-11-8-12-16-22)23(26)27-18-17-25(3)4/h7-16,20H,5-6,17-19H2,1-4H3 ; Key:FPTOUQZVCUIPHY-UHFFFAOYSA-N ;
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Latest revision as of 19:41, 18 August 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during childbirth.^[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.^[2]

Mechanism of action

Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.^[3]

References

↑ Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report
↑ Dootz, H; Kuhlmann, A; Hoffmann, K (eds.). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN 3-87193-306-6.
↑ Dinnendahl, V, Fricke, U, ed. (2010). Arzneistoff-Profile (in German). 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.

[1] Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report

[2] Dootz, H; Kuhlmann, A; Hoffmann, K (eds.). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN 3-87193-306-6.

[Arzneistoff-Profile-3] Dinnendahl, V, Fricke, U, ed. (2010). Arzneistoff-Profile (in German). 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.

[1]

[2]

[3]

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Clinical data

AHFS/Drugs.com	International Drug Names
Pregnancy category	Gr 1 (Germany)
Routes of administration	intramuscular injection, suppositories
ATCvet code	Template:Infobox drug/formatATCvet Template:Infobox drug/formatATCvet
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	8% (suppositories), 37% (oral solution)
Metabolism	mainly hepatic, at least 11 metabolites
Elimination half-life	34 hours
Identifiers
IUPAC name 2-(Dimethylamino)ethyl (2-ethylbutoxy)diphenylacetate
CAS Number	3579-62-2^Y 3321-06-0 (hydrochloride)
PubChem CID	71130
ChemSpider	64278^N
UNII	O14NF38MTL
KEGG	D07787^Y
ChEMBL	ChEMBL1614656^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₄H₃₃NO₃
Molar mass	383.52 g/mol
3D model (JSmol)	Interactive image
SMILES CCC(CC)COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(C)C
InChI InChI=1S/C24H33NO3/c1-5-20(6-2)19-28-24(21-13-9-7-10-14-21,22-15-11-8-12-16-22)23(26)27-18-17-25(3)4/h7-16,20H,5-6,17-19H2,1-4H3^N Key:FPTOUQZVCUIPHY-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Denaverine: Difference between revisions

Latest revision as of 19:41, 18 August 2015

Overview

Mechanism of action

References

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