Teratoma classification: Difference between revisions
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{{CMG}} {{AE}} {{MD}} | {{CMG}} {{AE}} {{MD}} | ||
==Classification== | ==Classification== | ||
*GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.[4,5] Childhood extracranial GCTs can be divided into the following two types: | *1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.[4,5] Childhood extracranial GCTs can be divided into the following two types: | ||
:*Gonadal. | :* Gonadal. | ||
:*Extragonadal. | :* Extragonadal. | ||
*Most childhood extragonadal GCTs arise in midline sites (i.e., sacrococcygeal, mediastinal, and retroperitoneal); the midline location may represent aberrant embryonic migration of the primordial germ cells. | *2. Most childhood extragonadal GCTs arise in midline sites (i.e., sacrococcygeal, mediastinal, and retroperitoneal); the midline location may represent aberrant embryonic migration of the primordial germ cells. | ||
*Childhood extracranial GCTs are broadly classified as the following: | :* Childhood extracranial GCTs are broadly classified as the following: | ||
:*Mature teratomas. | ::* Mature teratomas. | ||
:*Immature teratomas. | ::* Immature teratomas. | ||
:*Malignant GCTs. | ::* Malignant GCTs. | ||
:*GCTs comprise a variety of histologic diagnoses and can also be divided into the following histologic types: | ::* GCTs comprise a variety of histologic diagnoses and can also be divided into the following histologic types: | ||
:*Germinoma. | ::* Germinoma. | ||
:*Germinoma. | ::* Germinoma. | ||
:*Dysgerminoma (ovary). | ::* Dysgerminoma (ovary). | ||
:*Seminoma (testis). | ::* Seminoma (testis). | ||
:*Nongerminoma. | ::* Nongerminoma. | ||
:*Teratoma (mature and immature). | ::* Teratoma (mature and immature). | ||
:*Yolk sac tumor (endodermal sinus tumor). | ::* Yolk sac tumor (endodermal sinus tumor). | ||
Choriocarcinoma. | ::* Choriocarcinoma. | ||
Embryonal carcinoma. | ::* Embryonal carcinoma. | ||
Gonadoblastoma. | ::* Gonadoblastoma. | ||
Mixed GCT | ::* Mixed GCT | ||
Revision as of 18:15, 19 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
Classification
- 1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.[4,5] Childhood extracranial GCTs can be divided into the following two types:
- Gonadal.
- Extragonadal.
- 2. Most childhood extragonadal GCTs arise in midline sites (i.e., sacrococcygeal, mediastinal, and retroperitoneal); the midline location may represent aberrant embryonic migration of the primordial germ cells.
- Childhood extracranial GCTs are broadly classified as the following:
- Mature teratomas.
- Immature teratomas.
- Malignant GCTs.
- GCTs comprise a variety of histologic diagnoses and can also be divided into the following histologic types:
- Germinoma.
- Germinoma.
- Dysgerminoma (ovary).
- Seminoma (testis).
- Nongerminoma.
- Teratoma (mature and immature).
- Yolk sac tumor (endodermal sinus tumor).
- Choriocarcinoma.
- Embryonal carcinoma.
- Gonadoblastoma.
- Mixed GCT