Teratoma classification: Difference between revisions
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{{Teratoma}} | {{Teratoma}} | ||
{{CMG}} {{AE}} {{MD}} | {{CMG}} {{AE}} {{MD}} | ||
==Classification== | ==Classification== | ||
*1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.[4,5] Childhood extracranial GCTs can be divided into the following two types: | * '''Childhood Extracranial Germ Cell Tumors classification''' | ||
:* Gonadal. | :* 1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.[4,5] Childhood extracranial GCTs can be divided into the following two types: | ||
:* Extragonadal. | ::* Gonadal. | ||
*2. Most childhood extragonadal GCTs arise in midline sites (i.e., sacrococcygeal, mediastinal, and retroperitoneal); the midline location may represent aberrant embryonic migration of the primordial germ cells. | ::* Extragonadal. | ||
:* Childhood extracranial GCTs are broadly classified as the following: | :* 2. Most childhood extragonadal GCTs arise in midline sites (i.e., sacrococcygeal, mediastinal, and retroperitoneal); the midline location may represent aberrant embryonic migration of the primordial germ cells. | ||
::* Mature teratomas. | ::* Childhood extracranial GCTs are broadly classified as the following: | ||
::* Immature teratomas. | :::* Mature teratomas. | ||
::* Malignant GCTs. | :::* Immature teratomas. | ||
::* GCTs comprise a variety of histologic diagnoses and can also be divided into the following histologic types: | :::* Malignant GCTs. | ||
::* Germinoma. | :::* GCTs comprise a variety of histologic diagnoses and can also be divided into the following histologic types: | ||
::* Germinoma. | :::* Germinoma. | ||
::* Dysgerminoma (ovary). | :::* Germinoma. | ||
::* Seminoma (testis). | :::* Dysgerminoma (ovary). | ||
::* Nongerminoma. | :::* Seminoma (testis). | ||
::* Teratoma (mature and immature). | :::* Nongerminoma. | ||
::* Yolk sac tumor (endodermal sinus tumor). | :::* Teratoma (mature and immature). | ||
::* Choriocarcinoma. | :::* Yolk sac tumor (endodermal sinus tumor). | ||
::* Embryonal carcinoma. | :::* Choriocarcinoma. | ||
::* Gonadoblastoma. | :::* Embryonal carcinoma. | ||
::* Mixed GCT | :::* Gonadoblastoma. | ||
:::* Mixed GCT | |||
==References== | ==References== |
Revision as of 18:19, 19 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
==Classification==
- Childhood Extracranial Germ Cell Tumors classification
- 1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.[4,5] Childhood extracranial GCTs can be divided into the following two types:
- Gonadal.
- Extragonadal.
- 2. Most childhood extragonadal GCTs arise in midline sites (i.e., sacrococcygeal, mediastinal, and retroperitoneal); the midline location may represent aberrant embryonic migration of the primordial germ cells.
- Childhood extracranial GCTs are broadly classified as the following:
- Mature teratomas.
- Immature teratomas.
- Malignant GCTs.
- GCTs comprise a variety of histologic diagnoses and can also be divided into the following histologic types:
- Germinoma.
- Germinoma.
- Dysgerminoma (ovary).
- Seminoma (testis).
- Nongerminoma.
- Teratoma (mature and immature).
- Yolk sac tumor (endodermal sinus tumor).
- Choriocarcinoma.
- Embryonal carcinoma.
- Gonadoblastoma.
- Mixed GCT