Adamantinoma: Difference between revisions

	WikiDoc Resources for Adamantinoma
Articles
Most recent articles on Adamantinoma Most cited articles on Adamantinoma Review articles on Adamantinoma Articles on Adamantinoma in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Adamantinoma Images of Adamantinoma Photos of Adamantinoma Podcasts & MP3s on Adamantinoma Videos on Adamantinoma
Evidence Based Medicine
Cochrane Collaboration on Adamantinoma Bandolier on Adamantinoma TRIP on Adamantinoma
Clinical Trials
Ongoing Trials on Adamantinoma at Clinical Trials.gov Trial results on Adamantinoma Clinical Trials on Adamantinoma at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Adamantinoma NICE Guidance on Adamantinoma NHS PRODIGY Guidance FDA on Adamantinoma CDC on Adamantinoma
Books
Books on Adamantinoma
News
Adamantinoma in the news Be alerted to news on Adamantinoma News trends on Adamantinoma
Commentary
Blogs on Adamantinoma
Definitions
Definitions of Adamantinoma
Patient Resources / Community
Patient resources on Adamantinoma Discussion groups on Adamantinoma Patient Handouts on Adamantinoma Directions to Hospitals Treating Adamantinoma Risk calculators and risk factors for Adamantinoma
Healthcare Provider Resources
Symptoms of Adamantinoma Causes & Risk Factors for Adamantinoma Diagnostic studies for Adamantinoma Treatment of Adamantinoma
Continuing Medical Education (CME)
CME Programs on Adamantinoma
International
Adamantinoma en Espanol Adamantinoma en Francais
Business
Adamantinoma in the Marketplace Patents on Adamantinoma
Experimental / Informatics
List of terms related to Adamantinoma

	Adamantinoma;
	Micrograph of an adamantinoma showing the biphasic histomorphology. H&E stain..
ICD-O:	9310/0
DiseasesDB	31676
MeSH	D050398

← Older edit Newer edit →

VisualWikitext

Revision as of 18:22, 19 August 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Adamantinoma is a rare bone cancer, making up less than 1% of all bone cancers. It predominantly arises in bone in a subcutaneous location (85% are in the tibia). Most commonly, patients are in their second or third decade, but it can occur over a wide age range.

Historical Perspective

The condition was first described by Fischer in 1913.^[1]^[2]

Prior name for ameloblastoma

The typically benign odontogenic tumor known as ameloblastoma was first recognized in 1827 by Cusack but did not yet have any designation.^[3] In 1885, this kind of odontogenic neoplasm was designated as an adamantinoma by Malassez^[4] and was finally renamed to the modern name ameloblastoma in 1930 by Ivey and Churchill.^[5]^[6] Some authors still confusingly misuse the term adamantinoma to describe ameloblastomas, however they differ in histology and frequency of malignancy.

Epidemiology and Demographics

Most commonly, patients are in their second or third decade, but adamantinoma can occur over a wide age range.

Risk Factors

Benign osteofibrous dysplasia may be a precursor of adamantinoma^[7]^[8] or a regressive phase of adamantinoma.^[9]

Pathophysiology

Gross Pathology

The tumor is typically well-demarcated, osteolytic and eccentric, with cystic zones resembling soap bubbles.^[10]

Microscopic Pathology

Islands of epithelial cells are found in a fibrous stroma.

Natural History,Complications,Prognosis

Complications

Metastases are rare at presentation but may occur in up to 30% of patients during the disease course.

Prognosis

Prognosis is excellent, with overall survival of 85% at 10 years, but is lower when wide surgical margins cannot be obtained.

History and Symptoms

Patients typically present with swelling in long bones with or without pain.

Physical Examination

Extremities

The slow-growing tumor predominantly arises in long bones in a subcortical location (95% in the tibia or fibula).^[11]

Treatment

Treatment consists of wide resection or amputation.This tumor is insensitive to radiation so chemotherapy is not typically used unless the cancer has metastized to the lungs or other organs.^[10]

References

↑ Invalid <ref> tag; no text was provided for refs named urlAdamantinoma: Overview - eMedicine
↑ Fischer B. Uber ein primares Adamantinom der Tibia. 12. Frankfurt: Zeitschr. f. Path.; 1913:422-441.
↑ Invalid <ref> tag; no text was provided for refs named Cusack
↑ Invalid <ref> tag; no text was provided for refs named Malassez
↑ Invalid <ref> tag; no text was provided for refs named Ivey
↑ Invalid <ref> tag; no text was provided for refs named Madhup
↑ Invalid <ref> tag; no text was provided for refs named pmid16636523
↑ Springfield DS, Rosenberg AE, Mankin HJ, Mindell ER. (1994). "Relationship between osteofibrous dysplasia and adamantinoma". Clin Orthop Relat Res. (309): 234–44. PMID 7994967.
↑ Gleason, Briana C., Liegl-Atzwanger, Bernadette. "Osteofibrous Dysplasia and Adamantinoma in Children and Adolescents: A Clinicopathologic Reappraisal". American Journal of Surgical Pathology. 32 (3): 363–376. doi:10.1097/PAS.0b013e318150d53e.
↑ ^10.0 ^10.1 Invalid <ref> tag; no text was provided for refs named Radiation
↑ Invalid <ref> tag; no text was provided for refs named pmid18279517

Campbell's Operative Orthopedics (10th edition ed.). 2003.CS1 maint: Extra text (link)

Template:Epithelial neoplasms

Template:WikiDoc Sources

[urlAdamantinoma:_Overview_-_eMedicine-1] Invalid <ref> tag; no text was provided for refs named urlAdamantinoma: Overview - eMedicine

[2] Fischer B. Uber ein primares Adamantinom der Tibia. 12. Frankfurt: Zeitschr. f. Path.; 1913:422-441.

[Cusack-3] Invalid <ref> tag; no text was provided for refs named Cusack

[Malassez-4] Invalid <ref> tag; no text was provided for refs named Malassez

[Ivey-5] Invalid <ref> tag; no text was provided for refs named Ivey

[Madhup-6] Invalid <ref> tag; no text was provided for refs named Madhup

[pmid16636523-7] Invalid <ref> tag; no text was provided for refs named pmid16636523

[8] Springfield DS, Rosenberg AE, Mankin HJ, Mindell ER. (1994). "Relationship between osteofibrous dysplasia and adamantinoma". Clin Orthop Relat Res. (309): 234–44. PMID 7994967.

[9] Gleason, Briana C., Liegl-Atzwanger, Bernadette. "Osteofibrous Dysplasia and Adamantinoma in Children and Adolescents: A Clinicopathologic Reappraisal". American Journal of Surgical Pathology. 32 (3): 363–376. doi:10.1097/PAS.0b013e318150d53e.

[Radiation-10] 10.0 ^10.1 Invalid <ref> tag; no text was provided for refs named Radiation

[pmid18279517-11] Invalid <ref> tag; no text was provided for refs named pmid18279517

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

@@ Line 22: / Line 22: @@
 ==Historical Perspective==
 The condition was first described by Fischer in 1913.<ref name="urlAdamantinoma: Overview - eMedicine"/><ref>Fischer B. Uber ein primares Adamantinom der Tibia. 12. Frankfurt: Zeitschr. f. Path.; 1913:422-441.</ref>
+===Prior name for ameloblastoma===
+The typically benign odontogenic tumor known as [[ameloblastoma]] was first recognized in 1827 by Cusack but did not yet have any designation.<ref name="Cusack"/>  In 1885, this kind of odontogenic neoplasm was designated as an ''adamantinoma'' by Malassez<ref name="Malassez"/> and was finally renamed to the modern name ''[[ameloblastoma]]'' in 1930 by Ivey and Churchill.<ref name="Ivey"/><ref name="Madhup"/> Some authors still confusingly misuse the term adamantinoma to describe ameloblastomas, however they differ in histology and frequency of malignancy.
+==Epidemiology and Demographics==
+Most commonly, patients are in their second or third decade, but adamantinoma can occur over a wide age range.
-==Prior name for ameloblastoma==
+==Risk Factors==
-The typically benign odontogenic tumor known as [[ameloblastoma]] was first recognized in 1827 by Cusack but did not yet have any designation.<ref name="Cusack"/>  In 1885, this kind of odontogenic neoplasm was designated as an ''adamantinoma'' by Malassez<ref name="Malassez"/> and was finally renamed to the modern name ''[[ameloblastoma]]'' in 1930 by Ivey and Churchill.<ref name="Ivey"/><ref name="Madhup"/> Some authors still confusingly misuse the term adamantinoma to describe ameloblastomas, however they differ in histology and frequency of malignancy.
+Benign osteofibrous dysplasia may be a precursor of adamantinoma<ref name="pmid16636523"/><ref>{{cite journal |url=http://www.ncbi.nlm.nih.gov/pubmed/7994967|title=Relationship between osteofibrous dysplasia and adamantinoma.| author=Springfield DS, Rosenberg AE, Mankin HJ, Mindell ER. |pmid=7994967 |journal=Clin Orthop Relat Res. |year=1994 |pages=234–44 |issue=309}}</ref> or a regressive phase of adamantinoma.<ref>{{cite journal |url=http://journals.lww.com/ajsp/Abstract/2008/03000/Osteofibrous_Dysplasia_and_Adamantinoma_in.3.aspx |title=Osteofibrous Dysplasia and Adamantinoma in Children and Adolescents: A Clinicopathologic Reappraisal |author=Gleason, Briana C., Liegl-Atzwanger, Bernadette |journal=American Journal of Surgical Pathology |issue=3 |volume=32 |pages=363–376 |doi= 10.1097/PAS.0b013e318150d53e}}</ref>
 ==Pathophysiology==
-Histologically, islands of epithelial cells are found in a fibrous stroma.
+===Gross Pathology===
+The tumor is typically well-demarcated, [[Osteolysis|osteolytic]] and eccentric, with cystic zones resembling soap bubbles.<ref name="Radiation" />
+===Microscopic Pathology===
+Islands of epithelial cells are found in a fibrous stroma.
+==Natural History,Complications,Prognosis==
+===Complications===
+Metastases are rare at presentation but may occur in up to 30% of patients during the disease course.
+===Prognosis===
+Prognosis is excellent, with overall survival of 85% at 10 years, but is lower when wide surgical margins cannot be obtained.
+==History and Symptoms==
+Patients typically present with swelling in long bones with or without pain.
+==Physical Examination==
+===Extremities===
+The slow-growing tumor predominantly arises in long bones in a subcortical location (95% in the [[tibia]] or [[fibula]]).<ref name="pmid18279517"/>
 ==Treatment==
-Treatment consists of wide resection or [[amputation]].  Metastases are rare at presentation but may occur in up to 30% of patients during the disease course.  Prognosis is excellent, with overall survival of 85% at 10 years, but is lower when wide surgical margins cannot be obtained.
+Treatment consists of wide resection or [[amputation]].This tumor is insensitive to radiation so [[chemotherapy]] is not typically used unless the cancer has [[Metastasis|metastized]] to the lungs or other organs.<ref name="Radiation" />
+==See also==
+*[[ameloblastoma]]
+*osteofibrous dysplasia
 ==References==
+{{reflist|2}}
 *{{cite book|title = Campbell's Operative Orthopedics|edition=10th edition|year=2003}}
@@ Line 42: / Line 68: @@
-[[it:Adamantinoma]]
-[[ka:ადამანტინომა]]
 {{WikiDoc Help Menu}}
 {{WikiDoc Sources}}


Adamantinoma
Micrograph of an adamantinoma showing the biphasic histomorphology. H&E stain..
ICD-O:	9310/0
DiseasesDB	31676
MeSH	D050398