Teratoma classification: Difference between revisions

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Revision as of 18:23, 19 August 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.[4,5] Childhood extracranial GCTs can be divided into the following two types:

2. Most childhood extragonadal GCTs arise in midline sites (i.e., sacrococcygeal, mediastinal, and retroperitoneal); the midline location may represent aberrant embryonic migration of the primordial germ cells.Childhood extracranial GCTs are broadly classified as the following:

3. GCTs comprise a variety of histologic diagnoses and can also be divided into the following histologic types:

@@ Line 7: / Line 7: @@
 ::* Gonadal.
 ::* Extragonadal.
-:* 2. Most childhood extragonadal GCTs arise in midline sites (i.e., sacrococcygeal, mediastinal, and retroperitoneal); the midline location may represent aberrant embryonic migration of the primordial germ cells.
+:* 2. Most childhood extragonadal GCTs arise in midline sites (i.e., sacrococcygeal, mediastinal, and retroperitoneal); the midline location may represent aberrant embryonic migration of the primordial germ cells.Childhood extracranial GCTs are broadly classified as the following:
-::* Childhood extracranial GCTs are broadly classified as the following:
 :::* Mature teratomas.
 :::* Immature teratomas.
 :::* Malignant GCTs.
-::* 3. GCTs comprise a variety of histologic diagnoses and can also be divided into the following histologic types:
+:* 3. GCTs comprise a variety of histologic diagnoses and can also be divided into the following histologic types:
 :::* Germinoma.
 :::* Germinoma.