Adamantinoma: Difference between revisions
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==Historical Perspective== | ==Historical Perspective== | ||
The condition was first described by Fischer in 1913.<ref name="urlAdamantinoma: Overview - eMedicine"/><ref>Fischer B. Uber ein primares Adamantinom der Tibia. 12. Frankfurt: Zeitschr. f. Path.; 1913:422-441.</ref> | The condition was first described by Fischer in 1913.<ref name="urlAdamantinoma: Overview - eMedicine"/><ref>Fischer B. Uber ein primares Adamantinom der Tibia. 12. Frankfurt: Zeitschr. f. Path.; 1913:422-441.</ref> | ||
The typically benign odontogenic tumor known as [[ameloblastoma]] was first recognized in 1827 by Cusack but did not yet have any designation.<ref name="Cusack">{{cite journal |title=Report of the amputations of the lower jaw |author=J.W. Cusack |journal=Dublin Hosp Rec |volume=4 |year=1827 |pages=1–38 }}</ref> In 1885, this kind of odontogenic neoplasm was designated as an ''adamantinoma'' by <ref name="Malassez">{{cite journal |title=Sur Le role des debris epitheliaux papdentaires |author=L. Malassez |year=1885 |journal=Arch Physiol Norm Pathol |volume=5 |pages=309–340 6:379–449 }}</ref>and was finally renamed to the modern name ''[[ameloblastoma]]'' in 1930 by Ivey and Churchill.<ref name="Ivey">{{cite journal |author=R.H. Ivey, H.R. Churchill, |title=The need of a standardized surgical and pathological classification of tumors and anomalies of dental origin, |journal=Am Assoc Dent Sch Trans |volume=7 |year=1930 |pages=240–245 }}</ref><ref name="Madhup">{{cite journal |title=Giant ameloblastoma of jaw successfully treated by radiotherapy |journal=Oral Oncology Extra |doi=10.1016/j.ooe.2005.08.004 |volume=42 |issue=1 |date=Jan 2006 |pages=22–25 |last1=Madhup |first1=R |last2=Kirti |first2=S |last3=Bhatt |first3=M |last4=Srivastava |first4=M |last5=Sudhir |first5=S |last6=Srivastava |first6=A }}</ref> Some authors still confusingly misuse the term adamantinoma to describe ameloblastomas, however they differ in histology and frequency of malignancy. | The typically benign odontogenic tumor known as [[ameloblastoma]] was first recognized in 1827 by Cusack but did not yet have any designation.<ref name="Cusack">{{cite journal |title=Report of the amputations of the lower jaw |author=J.W. Cusack |journal=Dublin Hosp Rec |volume=4 |year=1827 |pages=1–38 }}</ref> In 1885, this kind of odontogenic neoplasm was designated as an ''adamantinoma'' by <ref name="Malassez">{{cite journal |title=Sur Le role des debris epitheliaux papdentaires |author=L. Malassez |year=1885 |journal=Arch Physiol Norm Pathol |volume=5 |pages=309–340 6:379–449 }}</ref>and was finally renamed to the modern name ''[[ameloblastoma]]'' in 1930 by Ivey and Churchill.<ref name="Ivey">{{cite journal |author=R.H. Ivey, H.R. Churchill, |title=The need of a standardized surgical and pathological classification of tumors and anomalies of dental origin, |journal=Am Assoc Dent Sch Trans |volume=7 |year=1930 |pages=240–245 }}</ref><ref name="Madhup">{{cite journal |title=Giant ameloblastoma of jaw successfully treated by radiotherapy |journal=Oral Oncology Extra |doi=10.1016/j.ooe.2005.08.004 |volume=42 |issue=1 |date=Jan 2006 |pages=22–25 |last1=Madhup |first1=R |last2=Kirti |first2=S |last3=Bhatt |first3=M |last4=Srivastava |first4=M |last5=Sudhir |first5=S |last6=Srivastava |first6=A }}</ref> Some authors still confusingly misuse the term adamantinoma to describe ameloblastomas, however they differ in histology and frequency of malignancy. | ||
Revision as of 17:57, 20 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Adamantinoma is a rare bone cancer, making up less than 1% of all bone cancers. It predominantly arises in bone in a subcutaneous location (85% are in the tibia). Most commonly, patients are in their second or third decade, but it can occur over a wide age range.
Historical Perspective
The condition was first described by Fischer in 1913.[1][2] The typically benign odontogenic tumor known as ameloblastoma was first recognized in 1827 by Cusack but did not yet have any designation.[3] In 1885, this kind of odontogenic neoplasm was designated as an adamantinoma by [4]and was finally renamed to the modern name ameloblastoma in 1930 by Ivey and Churchill.[5][6] Some authors still confusingly misuse the term adamantinoma to describe ameloblastomas, however they differ in histology and frequency of malignancy.
Epidemiology and Demographics
Adamantinoma is a rare bone cancer, making up less than 1% of all bone cancers. Most commonly, patients are in their second or third decade, but adamantinoma can occur over a wide age range.
Risk Factors
Benign osteofibrous dysplasia may be a precursor of adamantinoma[7][8] or a regressive phase of adamantinoma.[9]
Pathophysiology
Gross Pathology
The tumor is typically well-demarcated, osteolytic and eccentric, with cystic zones.
Microscopic Pathology
Islands of epithelial cells are found in a fibrous stroma.
Natural History,Complications,Prognosis
Complications
Metastases are rare at presentation but may occur in up to 30% of patients during the disease course.
Prognosis
Prognosis is excellent, with overall survival of 85% at 10 years, but is lower when wide surgical margins cannot be obtained.
History and Symptoms
Patients typically present with swelling in long bones with or without pain.
Physical Examination
Extremities
The slow-growing tumor predominantly arises in long bones in a subcortical location (95% in the tibia or fibula).[10]
Diagnosis
X Ray
The tumor is typically well-demarcated, osteolytic and eccentric, with cystic zones resembling soap bubbles.[11]
Treatment
Treatment consists of wide resection or amputation.This tumor is insensitive to radiation so chemotherapy is not typically used unless the cancer has metastized to the lungs or other organs.[11]
See also
- ameloblastoma
- osteofibrous dysplasia
References
- ↑
- ↑ Fischer B. Uber ein primares Adamantinom der Tibia. 12. Frankfurt: Zeitschr. f. Path.; 1913:422-441.
- ↑ J.W. Cusack (1827). "Report of the amputations of the lower jaw". Dublin Hosp Rec. 4: 1–38.
- ↑ L. Malassez (1885). "Sur Le role des debris epitheliaux papdentaires". Arch Physiol Norm Pathol. 5: 309–340 6:379–449.
- ↑ R.H. Ivey, H.R. Churchill, (1930). "The need of a standardized surgical and pathological classification of tumors and anomalies of dental origin,". Am Assoc Dent Sch Trans. 7: 240–245.
- ↑ Madhup, R; Kirti, S; Bhatt, M; Srivastava, M; Sudhir, S; Srivastava, A (Jan 2006). "Giant ameloblastoma of jaw successfully treated by radiotherapy". Oral Oncology Extra. 42 (1): 22–25. doi:10.1016/j.ooe.2005.08.004.
- ↑ Hatori M, Watanabe M, Hosaka M, Sasano H, Narita M, Kokubun S (May 2006). "A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature". Tohoku J. Exp. Med. 209 (1): 53–9. doi:10.1620/tjem.209.53. PMID 16636523.
- ↑ Springfield DS, Rosenberg AE, Mankin HJ, Mindell ER. (1994). "Relationship between osteofibrous dysplasia and adamantinoma". Clin Orthop Relat Res. (309): 234–44. PMID 7994967.
- ↑ Gleason, Briana C., Liegl-Atzwanger, Bernadette. "Osteofibrous Dysplasia and Adamantinoma in Children and Adolescents: A Clinicopathologic Reappraisal". American Journal of Surgical Pathology. 32 (3): 363–376. doi:10.1097/PAS.0b013e318150d53e.
- ↑ Jain D, Jain VK, Vasishta RK, Ranjan P, Kumar Y (2008). "Adamantinoma: A clinicopathological review and update". Diagn Pathol. 3: 8. doi:10.1186/1746-1596-3-8. PMC 2276480. PMID 18279517.
- ↑ 11.0 11.1 Ernest U. Conrad (2008). Orthopaedic Oncology: Diagnosis and Treatment. Thieme. pp. 143–145.
- Campbell's Operative Orthopedics (10th edition ed.). 2003.