Pancreatic cancer primary prevention: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Pancreatic cancer}} | {{Pancreatic cancer}} | ||
{{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}} | {{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}};{{PSD}} | ||
==Overview== | ==Overview== | ||
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==Primary Prevention== | ==Primary Prevention== | ||
Prevention of pancreatic cancer consists of avoiding risk factors when possible<ref>http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_Can_pancreatic_cancer_be_prevented_34.asp?rnav=cri</ref> [[Tobacco smoking|Cigarette smoking]] is considered to be the most significant and avoidable risk factor for pancreatic cancer. Maintaining a healthy weight and exercising may be helpful. | :*Prevention of pancreatic cancer consists of avoiding risk factors when possible<ref>http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_Can_pancreatic_cancer_be_prevented_34.asp?rnav=cri</ref> | ||
The [[American Cancer Society]] recommends increasing consumption of fruits, vegetables, and whole grains while decreasing red meat intake. This has been questioned by several research groups.<ref> {{cite journal|title=Predictors of pancreatic cancer mortality among a large cohort of United States adults.|journal=Cancer Causes Control. |date=2000 Dec|first=SS|last=Coughlin |coauthors=Calle EE, Patel AV, Thun MJ.|volume=11|issue=10|pages=915-23.|id=PMID 11142526 |url=|format=|accessdate=2007-02-27}}</ref><ref> {{cite journal|title=A cohort study of smoking, alcohol consumption, and dietary factors for pancreatic cancer (United States).|journal=Cancer Causes Control. |date=1993 Sep|first=W|last=Zheng |coauthors=et al|volume=4|issue=5|pages=477-82. |id=PMID 8218880 |url=|format=|accessdate=2007-02-27}}</ref> | ::*[[Tobacco smoking|Cigarette smoking]] is considered to be the most significant and avoidable risk factor for pancreatic cancer. | ||
In 2006 a large prospective cohort study of over 80,000 subjects failed to prove a definite association.<ref> {{cite journal|title=Fruit and vegetable consumption in relation to pancreatic cancer risk: a prospective study.|journal=Cancer Epidemiology Biomarkers & Prevention|date=February 2006|first=Susanna|last=Larsson|coauthors=Niclas Håkansson, Ingmar Näslund, Leif Bergkvist and Alicja Wolk|volume=15|issue=|pages=301-305|id=PMID 16492919 |url=|format=|accessdate=2007-02-27}}</ref> The evidence in support of this lies mostly in small case-control studies. | ::*Maintaining a healthy weight and exercising may be helpful. | ||
In September 2006, a long-term study concluded that taking [[Vitamin D]] can substantially cut the risk of pancreatic cancer (as well as other cancers) by up to 50%.<ref>http://news.bbc.co.uk/1/hi/health/5334534.stm</ref><ref>http://www.webmd.com/content/article/127/116673.htm</ref><ref>http://www.forbes.com/forbeslife/health/feeds/hscout/2006/09/14/hscout534925.html</ref> More studies of this have been called for. | ::*The [[American Cancer Society]] recommends increasing consumption of fruits, vegetables, and whole grains while decreasing red meat intake. This has been questioned by several research groups.<ref> {{cite journal|title=Predictors of pancreatic cancer mortality among a large cohort of United States adults.|journal=Cancer Causes Control. |date=2000 Dec|first=SS|last=Coughlin |coauthors=Calle EE, Patel AV, Thun MJ.|volume=11|issue=10|pages=915-23.|id=PMID 11142526 |url=|format=|accessdate=2007-02-27}}</ref><ref> {{cite journal|title=A cohort study of smoking, alcohol consumption, and dietary factors for pancreatic cancer (United States).|journal=Cancer Causes Control. |date=1993 Sep|first=W|last=Zheng |coauthors=et al|volume=4|issue=5|pages=477-82. |id=PMID 8218880 |url=|format=|accessdate=2007-02-27}}</ref>In 2006 a large prospective cohort study of over 80,000 subjects failed to prove a definite association.<ref> {{cite journal|title=Fruit and vegetable consumption in relation to pancreatic cancer risk: a prospective study.|journal=Cancer Epidemiology Biomarkers & Prevention|date=February 2006|first=Susanna|last=Larsson|coauthors=Niclas Håkansson, Ingmar Näslund, Leif Bergkvist and Alicja Wolk|volume=15|issue=|pages=301-305|id=PMID 16492919 |url=|format=|accessdate=2007-02-27}}</ref> The evidence in support of this lies mostly in small case-control studies.In September 2006, a long-term study concluded that taking [[Vitamin D]] can substantially cut the risk of pancreatic cancer (as well as other cancers) by up to 50%.<ref>http://news.bbc.co.uk/1/hi/health/5334534.stm</ref><ref>http://www.webmd.com/content/article/127/116673.htm</ref><ref>http://www.forbes.com/forbeslife/health/feeds/hscout/2006/09/14/hscout534925.html</ref> More studies of this have been called for. | ||
Several studies, including one published June 1, 2007, indicate that B vitamins such as [[B12]], [[Vitamin B6|B6]], and [[folate]], can reduce the risk of pancreatic cancer when consumed in food, but not when ingested in vitamin tablet form.<ref>{{cite web |url=http://cancerres.aacrjournals.org/cgi/content/abstract/67/11/5553 |title=Plasma Folate, Vitamin B6, Vitamin B12, and Homocysteine and Pancreatic Cancer Risk in Four Large Cohorts -- Schernhammer et al. 67 (11): 5553 -- Cancer Research |accessdate=2007-06-04 |format= |work=}}</ref><ref>{{cite web |url=http://www.upi.com/Consumer_Health_Daily/Briefing/2007/06/01/pancreatic_cancer_risk_cut_by_b6_b12/3712/ |title=United Press International - Consumer Health Daily - Briefing |accessdate=2007-06-04 |format= |work=}}</ref> | ::*Several studies, including one published June 1, 2007, indicate that B vitamins such as [[B12]], [[Vitamin B6|B6]], and [[folate]], can reduce the risk of pancreatic cancer when consumed in food, but not when ingested in vitamin tablet form.<ref>{{cite web |url=http://cancerres.aacrjournals.org/cgi/content/abstract/67/11/5553 |title=Plasma Folate, Vitamin B6, Vitamin B12, and Homocysteine and Pancreatic Cancer Risk in Four Large Cohorts -- Schernhammer et al. 67 (11): 5553 -- Cancer Research |accessdate=2007-06-04 |format= |work=}}</ref><ref>{{cite web |url=http://www.upi.com/Consumer_Health_Daily/Briefing/2007/06/01/pancreatic_cancer_risk_cut_by_b6_b12/3712/ |title=United Press International - Consumer Health Daily - Briefing |accessdate=2007-06-04 |format= |work=}}</ref> | ||
==References== | ==References== | ||
Revision as of 18:36, 20 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2];Parminder Dhingra, M.D. [3]
Overview
Research suggest that lifestyle factors such as change in diet, exercise, and maintenance of weight, can influence the likelihood an individual develops pancreatic cancer.
Primary Prevention
- Prevention of pancreatic cancer consists of avoiding risk factors when possible[1]
- Cigarette smoking is considered to be the most significant and avoidable risk factor for pancreatic cancer.
- Maintaining a healthy weight and exercising may be helpful.
- The American Cancer Society recommends increasing consumption of fruits, vegetables, and whole grains while decreasing red meat intake. This has been questioned by several research groups.[2][3]In 2006 a large prospective cohort study of over 80,000 subjects failed to prove a definite association.[4] The evidence in support of this lies mostly in small case-control studies.In September 2006, a long-term study concluded that taking Vitamin D can substantially cut the risk of pancreatic cancer (as well as other cancers) by up to 50%.[5][6][7] More studies of this have been called for.
References
- ↑ http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_Can_pancreatic_cancer_be_prevented_34.asp?rnav=cri
- ↑ Coughlin, SS (2000 Dec). "Predictors of pancreatic cancer mortality among a large cohort of United States adults". Cancer Causes Control. 11 (10): 915-23. PMID 11142526. Unknown parameter
|coauthors=ignored (help); Check date values in:|date=(help);|access-date=requires|url=(help) - ↑ Zheng, W (1993 Sep). "A cohort study of smoking, alcohol consumption, and dietary factors for pancreatic cancer (United States)". Cancer Causes Control. 4 (5): 477-82. PMID 8218880. Unknown parameter
|coauthors=ignored (help); Check date values in:|date=(help);|access-date=requires|url=(help) - ↑ Larsson, Susanna (February 2006). "Fruit and vegetable consumption in relation to pancreatic cancer risk: a prospective study". Cancer Epidemiology Biomarkers & Prevention. 15: 301–305. PMID 16492919. Unknown parameter
|coauthors=ignored (help);|access-date=requires|url=(help) - ↑ http://news.bbc.co.uk/1/hi/health/5334534.stm
- ↑ http://www.webmd.com/content/article/127/116673.htm
- ↑ http://www.forbes.com/forbeslife/health/feeds/hscout/2006/09/14/hscout534925.html
- ↑ "Plasma Folate, Vitamin B6, Vitamin B12, and Homocysteine and Pancreatic Cancer Risk in Four Large Cohorts -- Schernhammer et al. 67 (11): 5553 -- Cancer Research". Retrieved 2007-06-04.
- ↑ "United Press International - Consumer Health Daily - Briefing". Retrieved 2007-06-04.