Fibrosarcoma: Difference between revisions
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== Pathophysiology == | == Pathophysiology == | ||
Tumor cells may resemble mature fibroblasts (spindle-shaped), secreting [[collagen]], with rare [[mitoses]]. These cells are arranged in short [[fascicles]] which split and merge, giving the appearance of "fish bone". Poorly differentiated tumors consist in more atypical cells, [[pleomorphic]], giant cells, [[multinucleated]], numerous atypical mitoses and reduced collagen production. Presence of immature blood vessels (sarcomatous vessels lacking [[endothelial]] cells) favors the bloodstream metastasizing. | Tumor cells may resemble mature fibroblasts (spindle-shaped), secreting [[collagen]], with rare [[mitoses]]. These cells are arranged in short [[fascicles]] which split and merge, giving the appearance of "fish bone". Poorly differentiated tumors consist in more atypical cells, [[pleomorphic]], giant cells, [[multinucleated]], numerous atypical mitoses and reduced collagen production. Presence of immature blood vessels (sarcomatous vessels lacking [[endothelial]] cells) favors the bloodstream metastasizing. | ||
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| [[Image:640px-Malignant peripheral nerve sheath tumour - high mag.jpg|thumb|350px|Micrograph of a tumour with the herringbone pattern as may be seen in fibrosarcoma. H&E stain.]] | |||
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Revision as of 23:50, 20 August 2015
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WikiDoc Resources for Fibrosarcoma |
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Articles |
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Most recent articles on Fibrosarcoma Most cited articles on Fibrosarcoma |
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Media |
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Powerpoint slides on Fibrosarcoma |
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Evidence Based Medicine |
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Clinical Trials |
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Ongoing Trials on Fibrosarcoma at Clinical Trials.gov Clinical Trials on Fibrosarcoma at Google
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Guidelines / Policies / Govt |
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US National Guidelines Clearinghouse on Fibrosarcoma
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Books |
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News |
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Commentary |
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Definitions |
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Patient Resources / Community |
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Patient resources on Fibrosarcoma Discussion groups on Fibrosarcoma Patient Handouts on Fibrosarcoma Directions to Hospitals Treating Fibrosarcoma Risk calculators and risk factors for Fibrosarcoma
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Healthcare Provider Resources |
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Causes & Risk Factors for Fibrosarcoma |
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Continuing Medical Education (CME) |
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International |
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Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Malignant fibromatous neoplasm, fibroblastic sarcoma
Overview
Fibrosarcoma (fibroblastic sarcoma) is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells.
Classificaion
Fibrosarcoma may be classified according to degrees of differentiation into three subtypes: low grade malignancy (differentiated), intermediate malignancy and high grade malignancy (anaplastic)
Pathophysiology
Tumor cells may resemble mature fibroblasts (spindle-shaped), secreting collagen, with rare mitoses. These cells are arranged in short fascicles which split and merge, giving the appearance of "fish bone". Poorly differentiated tumors consist in more atypical cells, pleomorphic, giant cells, multinucleated, numerous atypical mitoses and reduced collagen production. Presence of immature blood vessels (sarcomatous vessels lacking endothelial cells) favors the bloodstream metastasizing.
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Epidemiology and Demographics
Patients of all age groups may develop Fibrosarcoma, but are most common between the third and sixth decades of life. In infants, fibrosarcoma is usually congenital. Infants presenting with fibrosarcoma usually do so in the first two years of their life.
See also
References