Brain tumor risk factors: Difference between revisions
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* Genetic - The most common chromosomal changes in brain tumors occur on chromosomes 1, 10, 13, 17, 19, and 22. Changes on chromosomes 1 and 19 are most frequently found in [[oligodendroglioma]] and changes on chromosome 22 are most frequently found in [[meningioma]].<ref name="nlmnihgov">National Library of Medicine.http://www.nlm.nih.gov/medlineplus/cancer.html</ref> | * Genetic - The most common chromosomal changes in brain tumors occur on chromosomes 1, 10, 13, 17, 19, and 22. Changes on chromosomes 1 and 19 are most frequently found in [[oligodendroglioma]] and changes on chromosome 22 are most frequently found in [[meningioma]].<ref name="nlmnihgov">National Library of Medicine.http://www.nlm.nih.gov/medlineplus/cancer.html</ref> | ||
* The familial tumor syndromes and related chromosomal abnormalities that are associated with brain neoplasms include the following: | * The familial tumor syndromes and related chromosomal abnormalities that are associated with brain neoplasms include the following: | ||
**Neurofibromatosis type I (17q11) | **[[Neurofibromatosis type I]] (17q11) | ||
**Neurofibromatosis type II (22q12) | **[[Neurofibromatosis type II]] (22q12) | ||
** | **[[von Hippel-Lindau disease]] (3p25-26) | ||
**Tuberous sclerosis (9q34, 16p13) | **[[Tuberous sclerosis]] (9q34, 16p13) | ||
**Li-Fraumeni syndrome (17p13) | **[[Li-Fraumeni syndrome]] (17p13) | ||
**Turcot syndrome type 1 (3p21, 7p22) | **[[Turcot syndrome type 1]] (3p21, 7p22) | ||
**Turcot syndrome type 2 (5q21) | **[[Turcot syndrome type 2]] (5q21) | ||
**Nevoid basal cell carcinoma syndrome (9q22.3) | **[[Nevoid basal cell carcinoma syndrome]] (9q22.3) | ||
==References== | ==References== |
Revision as of 14:29, 21 August 2015
Brain tumor Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Brain tumors are associated with a number of predisposing risk factors such as radiation, inherited conditions like neurofibromatosis; von Hippel-Lindau syndrome; Li-Fraumeni syndrome; Turcot syndrome, viruses like Ebstein-Barr virus, chemicals like formaldehyde; vinyl chloride; acrylnitrile and genetic.
Risk Factors
There are many possible risk factors that could play a role.
- Radiation therapy to the brain, used to treat brain cancers, increases the risk for brain tumors up to 20 or 30 years afterwards.
- Exposure to radiation at work or to power lines, as well as head injuries, smoking, and hormone replacement therapy have NOT been proven to be risk factors.
- Most recent studies have found that cell phones, cordless phones, and wireless devices are safe and do not increase the risk.
- Lymphomas that begin in the brain in people with a weakened immune system are sometimes linked to the Epstein-Barr virus.
- Exposure to some chemicals. These chemicals are formaldehyde used by pathologists and embalmers. Vinyl chloride used in the manufacturing of plastics and acrylonitrile used in the manufacturing of textile and plastics
- A family history of brain cancer slightly increases the chance of developing brain cancer.
- Genetic - The most common chromosomal changes in brain tumors occur on chromosomes 1, 10, 13, 17, 19, and 22. Changes on chromosomes 1 and 19 are most frequently found in oligodendroglioma and changes on chromosome 22 are most frequently found in meningioma.[1]
- The familial tumor syndromes and related chromosomal abnormalities that are associated with brain neoplasms include the following:
- Neurofibromatosis type I (17q11)
- Neurofibromatosis type II (22q12)
- von Hippel-Lindau disease (3p25-26)
- Tuberous sclerosis (9q34, 16p13)
- Li-Fraumeni syndrome (17p13)
- Turcot syndrome type 1 (3p21, 7p22)
- Turcot syndrome type 2 (5q21)
- Nevoid basal cell carcinoma syndrome (9q22.3)
References
- ↑ National Library of Medicine.http://www.nlm.nih.gov/medlineplus/cancer.html