Melanoma causes: Difference between revisions
Jump to navigation
Jump to search
(→Causes) |
YazanDaaboul (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Melanoma}} | {{Melanoma}} | ||
{{CMG}} {{AE}} {{YD}} | |||
==Overview== | ==Overview== | ||
==Causes== | ==Causes== | ||
* | Melanoma may be caused by either sporadic genetic mutations (e.g. ''BRAF'' and/or ''N-RAS) or familial diseases. | ||
===Sporadic Melanooma=== | |||
*The majority of cases of melanoma are sporadic (90%). | |||
:* | *Melanoma is caused by multiple genetic mutations. | ||
*The most common mutations that result in the development of melanoma are ''BRAF'' (approximately 50% of melanomas) and N-RAS (approximately 15% of melanomas). | |||
===Familial Melanoma=== | |||
Melanoma may be caused by hereditary diseases (10%) and is associated with mutations of the ''CDKN2A'' gene: | |||
*Familial atypical multiple molde melanoma syndrome (FAMMM syndrome) | |||
*Melanoma-astrocytoma syndrome | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 22:04, 21 August 2015
|
Melanoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Melanoma causes On the Web |
|
American Roentgen Ray Society Images of Melanoma causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.
Overview
Causes
Melanoma may be caused by either sporadic genetic mutations (e.g. BRAF and/or N-RAS) or familial diseases.
Sporadic Melanooma
- The majority of cases of melanoma are sporadic (90%).
- Melanoma is caused by multiple genetic mutations.
- The most common mutations that result in the development of melanoma are BRAF (approximately 50% of melanomas) and N-RAS (approximately 15% of melanomas).
Familial Melanoma
Melanoma may be caused by hereditary diseases (10%) and is associated with mutations of the CDKN2A gene:
- Familial atypical multiple molde melanoma syndrome (FAMMM syndrome)
- Melanoma-astrocytoma syndrome