Craniopharyngioma (classification): Difference between revisions
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Craniopharyngiomas are believed to derive from Rathke cleft rather than [[squamous cell]] rests along the craniopharyngeal duct as was previously thought. This histological appearances of the two subtypes are different, accounting for the different ''imaging features''. | Craniopharyngiomas are believed to derive from Rathke cleft rather than [[squamous cell]] rests along the craniopharyngeal duct as was previously thought. This histological appearances of the two subtypes are different, accounting for the different ''imaging features''. | ||
*'''Adamantinomatous''' | *'''Adamantinomatous''' | ||
**This type is seen predominantly in ''children''. It consists of reticular epithelial cells which have appearances reminiscent of the enamel pulp of developing teeth. | **This type is seen predominantly in '''''children'''''. It consists of reticular epithelial cells which have appearances reminiscent of the enamel pulp of developing teeth. | ||
**There may be single or multiple cysts filled with thick oily fluid high in protein, blood products, and/or cholesterol, creating the so called "machinery oil". | **There may be single or multiple cysts filled with thick oily fluid high in protein, blood products, and/or cholesterol, creating the so called "machinery oil". | ||
**"Wet keratin nodules" are a characteristic histological feature. | **"Wet keratin nodules" are a characteristic histological feature. | ||
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*'''[[Papillary]]''' | *'''[[Papillary]]''' | ||
**The papillary subtype is seen almost exclusively in ''adults'' and is formed of masses of metaplastic squamous cells. | **The papillary subtype is seen almost exclusively in '''''adults''''' and is formed of masses of metaplastic squamous cells. | ||
**"Wet keratin" is absent. | **"Wet keratin" is absent. | ||
**''Cysts'' do form, but these are less of a feature, and the tumor is more ''solid''. | **''Cysts'' do form, but these are less of a feature, and the tumor is more ''solid''. | ||
Revision as of 18:13, 22 August 2015
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Overview
Classification
Craniopharyngiomas are believed to derive from Rathke cleft rather than squamous cell rests along the craniopharyngeal duct as was previously thought. This histological appearances of the two subtypes are different, accounting for the different imaging features.
- Adamantinomatous
- This type is seen predominantly in children. It consists of reticular epithelial cells which have appearances reminiscent of the enamel pulp of developing teeth.
- There may be single or multiple cysts filled with thick oily fluid high in protein, blood products, and/or cholesterol, creating the so called "machinery oil".
- "Wet keratin nodules" are a characteristic histological feature.
- Calcification is usually present: 90%.
- Papillary
- The papillary subtype is seen almost exclusively in adults and is formed of masses of metaplastic squamous cells.
- "Wet keratin" is absent.
- Cysts do form, but these are less of a feature, and the tumor is more solid.
- Calcification is uncommon or even rare.