Craniopharyngioma (classification): Difference between revisions
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==Overview== | ==Overview== | ||
==Classification== | ==Classification== | ||
Craniopharyngiomas are believed to derive from Rathke cleft rather than [[squamous cell]] rests along the craniopharyngeal duct as was previously thought. This histological appearances of the two subtypes are different, accounting for the different ''imaging features''. | Craniopharyngiomas are believed to derive from Rathke cleft rather than [[squamous cell]] rests along the craniopharyngeal duct as was previously thought. This histological appearances of the two subtypes are different, accounting for the different ''imaging features''.<ref>Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma</ref> | ||
*'''Adamantinomatous''' | *'''Adamantinomatous''' | ||
**This type is seen predominantly in '''''children'''''. It consists of reticular epithelial cells which have appearances reminiscent of the enamel pulp of developing teeth. | **This type is seen predominantly in '''''children'''''. It consists of reticular epithelial cells which have appearances reminiscent of the enamel pulp of developing teeth.<ref>Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma</ref> | ||
**There may be single or multiple cysts filled with thick oily fluid high in protein, blood products, and/or cholesterol, creating the so called "machinery oil". | **There may be single or multiple cysts filled with thick oily fluid high in protein, blood products, and/or cholesterol, creating the so called "machinery oil".<ref>Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma</ref> | ||
**"Wet keratin nodules" are a characteristic histological feature. | **"Wet keratin nodules" are a characteristic histological feature.<ref>Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma</ref> | ||
**Calcification is usually present: 90%. | **Calcification is usually present: 90%.<ref>Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma</ref> | ||
*'''[[Papillary]]''' | *'''[[Papillary]]''' | ||
**The papillary subtype is seen almost exclusively in '''''adults''''' and is formed of masses of metaplastic squamous cells. | **The papillary subtype is seen almost exclusively in '''''adults''''' and is formed of masses of metaplastic squamous cells.<ref>Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma</ref> | ||
**"Wet keratin" is absent. | **"Wet keratin" is absent.<ref>Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma</ref> | ||
**''Cysts'' do form, but these are less of a feature, and the tumor is more ''solid''. | **''Cysts'' do form, but these are less of a feature, and the tumor is more ''solid''.<ref>Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma</ref> | ||
**Calcification is uncommon or even rare. | **Calcification is uncommon or even rare.<ref>Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma</ref> | ||
==References== | ==References== | ||
Revision as of 18:18, 22 August 2015
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Overview
Classification
Craniopharyngiomas are believed to derive from Rathke cleft rather than squamous cell rests along the craniopharyngeal duct as was previously thought. This histological appearances of the two subtypes are different, accounting for the different imaging features.[1]
- Adamantinomatous
- This type is seen predominantly in children. It consists of reticular epithelial cells which have appearances reminiscent of the enamel pulp of developing teeth.[2]
- There may be single or multiple cysts filled with thick oily fluid high in protein, blood products, and/or cholesterol, creating the so called "machinery oil".[3]
- "Wet keratin nodules" are a characteristic histological feature.[4]
- Calcification is usually present: 90%.[5]
References
- ↑ Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma
- ↑ Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma
- ↑ Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma
- ↑ Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma
- ↑ Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma
- ↑ Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma
- ↑ Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma
- ↑ Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma
- ↑ Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma