Craniopharyngioma medical therapy: Difference between revisions
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*The mainstay of therapy for craniopharyngioma is surgery with or without radiation. Although systemic therapy is generally not utilized, it has been shown that the use of '''subcutaneous pegylated [[interferon]] alpha-2b''' to manage ''cystic recurrences'' can result in durable responses.<ref>Rx of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc</ref> | *The mainstay of therapy for craniopharyngioma is surgery with or without radiation. Although systemic therapy is generally not utilized, it has been shown that the use of '''subcutaneous pegylated [[interferon]] alpha-2b''' to manage ''cystic recurrences'' can result in durable responses.<ref>Rx of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc</ref> | ||
*The chemotherapy drugs [[Paclitaxel]] and [[Carboplatin]] have shown a clinical (but not statistical) significance in increasing the survival rate in patients who've had gross total resections of their malignant tumors. | *The chemotherapy drugs [[Paclitaxel]] and [[Carboplatin]] have shown a clinical (but not statistical) significance in increasing the survival rate in patients who've had gross total resections of their malignant tumors. | ||
*Cystic recurrences may be treated with intracavitary instillation of varying agents via [[stereotactic]] delivery or placement of an Ommaya catheter. These agents have included radioactive P-32 or other radioactive compounds, [[bleomycin]] or [[interferon-alpha]]. These strategies have been found to be useful in certain cases, and a low risk of complications has been reported. However, none of these approaches have shown efficacy against solid portions of the tumor.<ref>Rx of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc</ref> | *''Cystic recurrences'' may be treated with intracavitary instillation of varying agents via [[stereotactic]] delivery or placement of an Ommaya catheter. These agents have included radioactive P-32 or other radioactive compounds, [[bleomycin]] or [[interferon-alpha]]. These strategies have been found to be useful in certain cases, and a low risk of complications has been reported. However, none of these approaches have shown efficacy against solid portions of the tumor.<ref>Rx of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc</ref> | ||
==References== | ==References== | ||
Revision as of 18:52, 23 August 2015
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Craniopharyngioma medical therapy On the Web |
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American Roentgen Ray Society Images of Craniopharyngioma medical therapy |
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Risk calculators and risk factors for Craniopharyngioma medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Patients with craniopharyngioma have many treatment options. The selection depends on the size, location of the tumor. The options are surgery, radiation therapy, chemotherapy, or a combination of these methods.
Medical Therapy
- The mainstay of therapy for craniopharyngioma is surgery with or without radiation. Although systemic therapy is generally not utilized, it has been shown that the use of subcutaneous pegylated interferon alpha-2b to manage cystic recurrences can result in durable responses.[1]
- The chemotherapy drugs Paclitaxel and Carboplatin have shown a clinical (but not statistical) significance in increasing the survival rate in patients who've had gross total resections of their malignant tumors.
- Cystic recurrences may be treated with intracavitary instillation of varying agents via stereotactic delivery or placement of an Ommaya catheter. These agents have included radioactive P-32 or other radioactive compounds, bleomycin or interferon-alpha. These strategies have been found to be useful in certain cases, and a low risk of complications has been reported. However, none of these approaches have shown efficacy against solid portions of the tumor.[2]
References
- ↑ Rx of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc
- ↑ Rx of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc