Langerhans cell histiocytosis history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Features can be non-specific from generalized inflammatory response e.g fever, lethargy, weight loss or can be due to specific organ involvement.

History and Symptoms

• Histiocytosis X often affects the whole body. A disease that affects the whole body is called a systemic disorder.

• Symptoms can vary between children and adults, although there can be some overlap. Tumors in weight-bearing bones, such as the legs or spine, may cause the bones to fracture without apparent reason.

• Symptoms in children may include:

• Abdominal pain
• Bone pain (possibly)
• Delayed puberty
• Dizziness
• Ear drainage that continues long-term
• Eyes that appear to stick out (protrude) more and more
• Irritability
• Failure to thrive
• Fever
• Frequent urination
• Headache
• Jaundice
• Limping
• Mental deterioration
• Rash (petechiae or purpura)
• Seborrheic dermatitis of the scalp
• Seizures
• Short stature
• Swollen lymph glands
• Thirst
• Vomiting
• Weight loss

Note: Children over 5 years old often have only bone involvement.

• Symptoms in adults may include:

• Bone pain
• Chest pain
• Cough
• Fever
• General discomfort, uneasiness, or ill feeling (malaise)
• Increased amount of urine
• Rash
• Shortness of breath
• Thirst and increased drinking of fluids
• Weight loss

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