Renal cell carcinoma history and symptoms: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
Shanshan Cen (talk | contribs) |
||
| Line 12: | Line 12: | ||
===Local Symptoms=== | ===Local Symptoms=== | ||
The presence of local signs is considered a poor prognostic marker<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref>. Common local symptoms are listed below<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref>: | The presence of local signs is considered a poor prognostic marker<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref>. Common local symptoms are listed below<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref>: | ||
*Hematuria | *[[Hematuria]] | ||
*Flank pain | *[[Flank pain]] | ||
*Palpable abdominal mass | *Palpable [[abdominal mass]] | ||
===Systemic Symptoms=== | ===Systemic Symptoms=== | ||
The presence of systemic symptoms is mostly due to the presence of a paraneoplastic syndrome, mostly due to the presence of parathyroid-related protein (PTHrp) or a metastasis.<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref> Common systemic symptoms are listed below<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref>: | The presence of systemic symptoms is mostly due to the presence of a paraneoplastic syndrome, mostly due to the presence of parathyroid-related protein (PTHrp) or a metastasis.<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref> Common systemic symptoms are listed below<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref>: | ||
*Hypertension (renin secretion) | *[[Hypertension]] (renin secretion) | ||
*Hypercalcemia (PTHrp secretion) | *[[Hypercalcemia]] (PTHrp secretion) | ||
*Flushing (Erythroprotein secretion) | *[[Flushing]] (Erythroprotein secretion) | ||
*Fever | *[[Fever]] | ||
*Fatigue | *[[Fatigue]] | ||
*Weight loss | *[[Weight loss]] | ||
*Anorexia | *[[Anorexia]] | ||
*Muscle atrophy | *[[Muscle atrophy]] | ||
==References== | ==References== | ||
Revision as of 19:08, 24 August 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
|
Renal cell carcinoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Renal cell carcinoma history and symptoms On the Web |
|
American Roentgen Ray Society Images of Renal cell carcinoma history and symptoms |
|
Risk calculators and risk factors for Renal cell carcinoma history and symptoms |
Overview
Most patients follow an asymptomatic course. Among symptomatic patients, hematuria accounts for 60% of symptoms and is considered the most common symptom of patients with renal cell carcinoma.
Symptoms
Patients with renal cell carcinoma typically present at 60-70 years of age. The most common diagnosis of renal cell carcinoma is based on the incidental finding; whereby most patients are asymptomatic. Symptoms are often classified as local and systemic.
Local Symptoms
The presence of local signs is considered a poor prognostic marker[1]. Common local symptoms are listed below[1]:
- Hematuria
- Flank pain
- Palpable abdominal mass
Systemic Symptoms
The presence of systemic symptoms is mostly due to the presence of a paraneoplastic syndrome, mostly due to the presence of parathyroid-related protein (PTHrp) or a metastasis.[1] Common systemic symptoms are listed below[1]:
- Hypertension (renin secretion)
- Hypercalcemia (PTHrp secretion)
- Flushing (Erythroprotein secretion)
- Fever
- Fatigue
- Weight loss
- Anorexia
- Muscle atrophy
References
- ↑ 1.0 1.1 1.2 1.3 Rini BI, Campbell SC, Escudier B (2009). "Renal cell carcinoma". Lancet. 373 (9669): 1119–32. doi:10.1016/S0140-6736(09)60229-4. PMID 19269025.