Adrenocortical carcinoma history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
Adrenocortical carcinoma may present differently in children and adults. Most tumors in children are functional, and [[virilization]] is by far the most common presenting symptom, followed by [[Cushing's syndrome]] and [[precocious puberty]]. Among adults presenting with hormonal syndromes, Cushing's syndrome alone is most common, followed by mixed Cushing's and virilization ([[glucocorticoid]] and [[androgen]] overproduction). [[Feminization]] and [[Conn syndrome]] ([[mineralcorticoid]] excess) occur in less than 10% of cases. Rarely, [[pheochromocytoma]]-like hypersecretion of [[catecholamine]]s has been reported in adrenocortical cancers.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref> Non-functional tumors (about 40%, authorities vary) usually present with abdominal or flank pain, or they may be asymptomatic and detected incidentally. | |||
==History== | ==History== | ||
==Common symptoms== | ==Common symptoms== | ||
All patients with suspected adrenocortical carcinoma should be carefully evaluated for signs and symptoms of hormonal syndromes. | All patients with suspected adrenocortical carcinoma should be carefully evaluated for signs and symptoms of hormonal syndromes. | ||
This may include the followings: | This may include the followings: | ||
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:*Purple lines on the abdomen | :*Purple lines on the abdomen | ||
:*[[Buffalo hump]] | :*[[Buffalo hump]] | ||
:*[[Moon face| | :*[[Moon face|Moonlike face]] | ||
:*Thin, fragile skin. | :*Thin, fragile skin. | ||
2-[[Androgen]] excess symptoms (most readily noted in females) include: | 2-[[Androgen]] excess symptoms (most readily noted in females) include: | ||
| Line 30: | Line 29: | ||
:*[[Confusion]] | :*[[Confusion]] | ||
:*[[Palpitations]] | :*[[Palpitations]] | ||
4-[[Estrogen]] excess symptoms (most readily noted in males)include: | |||
:*[[Gynecomastia|breast enlargement]] | :*[[Gynecomastia|breast enlargement]] | ||
:*Decreased [[libido]] | :*Decreased [[libido]] | ||
Revision as of 19:40, 25 August 2015
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Adrenocortical carcinoma Microchapters |
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Differentiating Adrenocortical carcinoma from other Diseases |
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Adrenocortical carcinoma history and symptoms On the Web |
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Risk calculators and risk factors for Adrenocortical carcinoma history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]Ahmad Al Maradni, M.D. [3]
Overview
Adrenocortical carcinoma may present differently in children and adults. Most tumors in children are functional, and virilization is by far the most common presenting symptom, followed by Cushing's syndrome and precocious puberty. Among adults presenting with hormonal syndromes, Cushing's syndrome alone is most common, followed by mixed Cushing's and virilization (glucocorticoid and androgen overproduction). Feminization and Conn syndrome (mineralcorticoid excess) occur in less than 10% of cases. Rarely, pheochromocytoma-like hypersecretion of catecholamines has been reported in adrenocortical cancers.[1] Non-functional tumors (about 40%, authorities vary) usually present with abdominal or flank pain, or they may be asymptomatic and detected incidentally.
History
Common symptoms
All patients with suspected adrenocortical carcinoma should be carefully evaluated for signs and symptoms of hormonal syndromes. This may include the followings:
1- Glucocorticoid excess symptoms include:
- Weight gain
- Muscle wasting
- Purple lines on the abdomen
- Buffalo hump
- Moonlike face
- Thin, fragile skin.
2-Androgen excess symptoms (most readily noted in females) include:
- excess facial and body hair
- Acne
- Clitoromegaly
- Deepening of the voice
- Coarsening of facial features
- Cessation of menstruation.
3-Mineralcorticoid excess symptoms include:
4-Estrogen excess symptoms (most readily noted in males)include:
- breast enlargement
- Decreased libido
- Impotence.[2]
References
- ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
- ↑ Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL. Harrison's Principles of Internal Medicine. New York: McGraw-Hill, 2005. ISBN 0-07-139140-1