Acute lymphoblastic leukemia classification: Difference between revisions
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{{CMG}} {{AE}} {{RT}} | {{CMG}} {{AE}} {{RT}} | ||
== Overview == | == Overview == | ||
Acute lymphoblastic leukemia may be classified according to the French-American-British classification (FAB) and World Health Organization classification (WHO). The French-American-British classification is divided into 3 groups: ALL-L1: small uniform cells, ALL-L2: large varied cells, ALL-L3: large varied cells with [[vacuole]]s (bubble-like features). The World Health Organization classification is divided into three 3 too: B lymphoblastic leukemia/lymphoma, B lymphoblastic leukemia/lymphoma (Not organ specific), B lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities. | |||
== Classification == | |||
There are 2 classifications regard acute lymphoblastic leukemia, the French-American-British classification and the World Health Organization here you can find a description of both. | |||
===French-American-British classification=== | ===French-American-British classification=== | ||
The [[French-American-British classification | French-American-British (FAB) classification]] | The [[French-American-British classification | French-American-British (FAB) classification]] of acute lymphoblastic leukemia is divided into 3 subtypes L1 to L3 based on the type of cell from which the leukemia developed and its degree of maturity and morphological classification. Each subtype is then further classified by determining the surface markers of the abnormal lymphocytes, called immunophenotyping. There are 2 main immunologic types: pre-B cell and pre-T cell. The mature B-cell acute lymphoblastic leukemia (L3) is now classified as Burkitt leukemia/lymphoma. | ||
* ALL-L1: small uniform cells | * ALL-L1: small uniform cells | ||
* ALL-L2: large varied cells | * ALL-L2: large varied cells | ||
* ALL-L3: large varied cells with [[vacuole]]s (bubble-like features) | * ALL-L3: large varied cells with [[vacuole]]s (bubble-like features) | ||
===World Health Organization classification === | ===World Health Organization classification === | ||
The [[World Health Organization]] (WHO) classification of | The [[World Health Organization]] (WHO) classification of acute lymphoblastic leukemia attempts to be more clinically useful and to produce more meaningful prognostic information than the [[French-American-British classification | French-American-British (FAB) classification]] criteria. There are 3 different grups of Lymphoblastic leukemias according to the WHO including a classification with recurrent genetic abnormalities. | ||
===Group 1=== | ===Group 1=== | ||
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:*B lymphoblastic leukemia/lymphoma with t(9;22)(q34;q11.2), ''BCR-ABL1'' | :*B lymphoblastic leukemia/lymphoma with t(9;22)(q34;q11.2), ''BCR-ABL1'' | ||
:*B lymphoblastic leukemia/lymphoma with t(v;11q23); MLL rearranged | :*B lymphoblastic leukemia/lymphoma with t(v;11q23); MLL rearranged | ||
:*B lymphoblastic leukemia/lymphoma with t(12;21)(p13;q22) TEL-AML1 (ETV6-RUNX1) | :*B lymphoblastic leukemia/lymphoma with t(12;21)(p13;q22) ''TEL-AML1'' (ETV6-RUNX1) | ||
:*B lymphoblastic leukemia/lymphoma with hyperdiploidy | :*B lymphoblastic leukemia/lymphoma with hyperdiploidy | ||
:*B lymphoblastic leukemia/lymphoma with hypodiploidy | :*B lymphoblastic leukemia/lymphoma with hypodiploidy | ||
:*B lymphoblastic leukemia/lymphoma with t(5;14)(q31;q32) IL3-IGH | :*B lymphoblastic leukemia/lymphoma with t(5;14)(q31;q32) ''IL3-IGH'' | ||
:*B lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) TCF3-PBX1 | :*B lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) ''TCF3-PBX1'' | ||
(Images shown below are courtesy of Melih Aktan MD, Istanbul Medical Faculty - Turkey, and Kyoto University - Japan) | (Images shown below are courtesy of Melih Aktan MD, Istanbul Medical Faculty - Turkey, and Kyoto University - Japan) | ||
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{| align="center" | {| align="center" | ||
|-valign="top" | |-valign="top" | ||
| [[Image:ALL-L1.jpg|thumb|ALL-L1]] | | [[Image:ALL-L1.jpg|thumb|ALL-L1: Small uniform cells subtype]] | ||
| [[Image:ALL-L1 0002.jpg|thumb|ALL-L1]] | | [[Image:ALL-L1 0002.jpg|thumb|ALL-L1: Large varied cells subtype]] | ||
|} | |} | ||
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{| align="center" | {| align="center" | ||
|-valign="top" | |-valign="top" | ||
| [[Image:ALL-L2 Hand mirror cell 0001.jpg|thumb|ALL-L2 Hand mirror cell]] | | [[Image:ALL-L2 Hand mirror cell 0001.jpg|thumb|ALL-L2: Large varied cells (Hand mirror cell)]] | ||
| [[Image:ALL-L2 0003.jpg|thumb|ALL-L2]] | | [[Image:ALL-L2 0003.jpg|thumb|ALL-L2: Large varied cells]] | ||
|} | |} | ||
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{| align="center" | {| align="center" | ||
|-valign="top" | |-valign="top" | ||
| [[Image:ALL-L2 0002.jpg|thumb|ALL-L2]] | | [[Image:ALL-L2 0002.jpg|thumb|ALL-L2: Large varied cells]] | ||
| [[Image:ALL-L3 0001.jpg|thumb|ALL-L3]] | | [[Image:ALL-L3 0001.jpg|thumb|ALL-L3: Large varied cells with vacuoles (bubble-like features]] | ||
|} | |} | ||
Revision as of 14:25, 28 August 2015
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Acute lymphoblastic leukemia Microchapters |
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Differentiating Acute lymphoblastic leukemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Acute lymphoblastic leukemia classification On the Web |
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American Roentgen Ray Society Images of Acute lymphoblastic leukemia classification |
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Directions to Hospitals Treating Acute lymphoblastic leukemia |
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Risk calculators and risk factors for Acute lymphoblastic leukemia classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
Acute lymphoblastic leukemia may be classified according to the French-American-British classification (FAB) and World Health Organization classification (WHO). The French-American-British classification is divided into 3 groups: ALL-L1: small uniform cells, ALL-L2: large varied cells, ALL-L3: large varied cells with vacuoles (bubble-like features). The World Health Organization classification is divided into three 3 too: B lymphoblastic leukemia/lymphoma, B lymphoblastic leukemia/lymphoma (Not organ specific), B lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities.
Classification
There are 2 classifications regard acute lymphoblastic leukemia, the French-American-British classification and the World Health Organization here you can find a description of both.
French-American-British classification
The French-American-British (FAB) classification of acute lymphoblastic leukemia is divided into 3 subtypes L1 to L3 based on the type of cell from which the leukemia developed and its degree of maturity and morphological classification. Each subtype is then further classified by determining the surface markers of the abnormal lymphocytes, called immunophenotyping. There are 2 main immunologic types: pre-B cell and pre-T cell. The mature B-cell acute lymphoblastic leukemia (L3) is now classified as Burkitt leukemia/lymphoma.
- ALL-L1: small uniform cells
- ALL-L2: large varied cells
- ALL-L3: large varied cells with vacuoles (bubble-like features)
World Health Organization classification
The World Health Organization (WHO) classification of acute lymphoblastic leukemia attempts to be more clinically useful and to produce more meaningful prognostic information than the French-American-British (FAB) classification criteria. There are 3 different grups of Lymphoblastic leukemias according to the WHO including a classification with recurrent genetic abnormalities.
Group 1
- B lymphoblastic leukemia/lymphoma
Group 2
- B lymphoblastic leukemia/lymphoma (Not organ specific)
Group 3
- B lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities:
- B lymphoblastic leukemia/lymphoma with t(9;22)(q34;q11.2), BCR-ABL1
- B lymphoblastic leukemia/lymphoma with t(v;11q23); MLL rearranged
- B lymphoblastic leukemia/lymphoma with t(12;21)(p13;q22) TEL-AML1 (ETV6-RUNX1)
- B lymphoblastic leukemia/lymphoma with hyperdiploidy
- B lymphoblastic leukemia/lymphoma with hypodiploidy
- B lymphoblastic leukemia/lymphoma with t(5;14)(q31;q32) IL3-IGH
- B lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) TCF3-PBX1
(Images shown below are courtesy of Melih Aktan MD, Istanbul Medical Faculty - Turkey, and Kyoto University - Japan)
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