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== Overview ==
== Overview ==
'''Adrenocortical carcinoma''', also '''adrenal cortical carcinoma''' (ACC) and '''adrenal cortex cancer''', is an aggressive [[cancer]] originating in the [[Adrenal cortex|cortex]] ([[steroid hormone]]-producing tissue) of the [[adrenal gland]]. Adrenocortical carcinoma is a rare tumor, with incidence of 1-2 per million population annually.<ref name="DeVita">{{cite book |author=edited by Vincent T. DeVita, Samuel Hellman, Steven A. Rosenberg |title=Cancer: principles & practice of oncology |publisher=Lippincott-Raven |location=Philadelphia |year=2005 |pages= |isbn=0-7817-4865-8 |oclc= |doi=}}</ref><ref name="UTDACC">{{cite web | last =Savarese | first =Diane MF | coauthors =Lynnette K Nieman| title =Clinical presentation and evaluation of adrenocortical tumors| work =UpToDate Online v. 15.1| publisher =UpToDate| date = August 8, 2006| url =http://www.uptodateonline.com/utd/content/topic.do?topicKey=adrenal/17707&type=A&selectedTitle=1~16 | accessdate =June 5, 2007}}</ref> Adrenocortical carcinoma has a bimodal distribution by age, with cases clustering in children under 6, and in adults 30-40 years old.<ref name="DeVita"/> Adenocortical carcinoma is remarkable for the many hormonal syndromes which can occur in patients with steroid hormone-producing ("functional") tumors, including [[Cushing's syndrome]], [[Conn syndrome]], [[virilization]], and [[feminization (biology)|feminization]]. Adrenocortical carcinoma has often invaded nearby tissues or [[metastasis|metastasized]] to distant organs at the time of diagnosis, and the overall 5-year survival rate is only 20-35%.<ref name="DeVita"/>
'''Adrenocortical carcinoma''', also '''adrenal cortical carcinoma''' (ACC) and '''adrenal cortex cancer''', is an aggressive [[cancer]] originating in the [[Adrenal cortex|cortex]] ([[steroid hormone]]-producing tissue) of the [[adrenal gland]]. Adenocortical carcinoma is remarkable for the many hormonal syndromes which can occur in patients with steroid hormone-producing ("functional") tumors, including [[Cushing's syndrome]], [[Conn syndrome]], [[virilization]], and [[feminization (biology)|feminization]].
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 19:36, 1 September 2015

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Overview

Adrenocortical carcinoma, also adrenal cortical carcinoma (ACC) and adrenal cortex cancer, is an aggressive cancer originating in the cortex (steroid hormone-producing tissue) of the adrenal gland. Adenocortical carcinoma is remarkable for the many hormonal syndromes which can occur in patients with steroid hormone-producing ("functional") tumors, including Cushing's syndrome, Conn syndrome, virilization, and feminization.

References

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