Acute myeloid leukemia pathophysiology: Difference between revisions

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| [[Image:Acute myeloid leukemia-M5b 0002.jpg|thumb|Acute myeloid leukemia-M5b - moderate amounts of cytoplasm and large nuclei with fine chromatin but without prominent nucleoli. Note presence of nuclear folds and creases, which are a characteristic feature of promonocytes. ]]
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Revision as of 14:23, 2 September 2015

Acute myeloid leukemia Microchapters

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Differentiating Acute myeloid leukemia from other Diseases

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Carlos A Lopez, M.D. [3]

Overview

Pathophysiology

The malignant cell in acute myeloid leukemia is the myeloblast. In normal hematopoiesis, the myeloblast is an immature precursor of myeloid white blood cells; a normal myeloblast will gradually mature into a mature white blood cell. However, in acute myeloid leukemia a single myeloblast accumulates genetic changes which "freeze" the cell in its immature state and prevent differentiation.[1] Such a mutation alone does not cause leukemia; however, when such a "differentiation arrest" is combined with other mutations which disrupt genes controlling proliferation, the result is the uncontrolled growth of an immature clone of cells, leading to the clinical entity of acute myeloid leukemia.[2]

Much of the diversity and heterogeneity of acute myeloid leukemia stems from the fact that leukemic transformation can occur at a number of different steps along the differentiation pathway.[3] Modern classification schemes for acute myeloid leukemia recognize that the characteristics and behavior of the leukemic cell (and the leukemia) may depend on the stage at which differentiation was halted.

Specific cytogenetic abnormalities can be found in many patients with acute myeloid leukemia; the types of chromosomal abnormalities often have prognostic significance.[4] The chromosomal translocations encode abnormal fusion proteins, usually transcription factors whose altered properties may cause the "differentiation arrest."[5] For example, in acute promyelocytic leukemia, the t(15;17) translocation produces a PML-RARα fusion protein which binds to the retinoic acid receptor element in the promoters of several myeloid-specific genes and inhibits myeloid differentiation.[6]

The clinical signs and symptoms of acute myeloid leukemia result from the fact that, as the leukemic clone of cells grows, it tends to displace or interfere with the development of normal blood cells in the bone marrow.[7] This leads to neutropenia, anemia, and thrombocytopenia. The symptoms of acute myeloid leukemia are in turn often due to the low numbers of these normal blood elements. In rare cases, patients can develop a chloroma, or solid tumor of leukemic cells outside the bone marrow, which can cause various symptoms depending on its location.

Microscopic Pathology

(Images shown below are courtesy of Melih Aktan MD., Istanbul Medical Faculty - Turkey, and Kyoto University - Japan)

File:Acute myeloid leukemia-M0 0001.jpg
Acute myeloid leukemia-M0 - lack of obvious myeloid differentiation by routine histologic examination and presence of myeloperoxidase in <3% of blasts. Morphologically, blasts are small to large with no granules or Auer rods
File:Acute myeloid leukemia-M1 0002.jpg
Acute myeloid leukemia-M1 - presence of more than 90% myeloblasts in blood
File:Acute myeloid leukemia-M1 peroxidase 0001.jpg
Acute myeloid leukemia-M1 peroxidase
File:Acute myeloid leukemia-M1 0005.jpg
Acute myeloid leukemia-M1 - more cytoplasm than M0, but still no granules
File:Acute myeloid leukemia-M1 0004.jpg
Acute myeloid leukemia-M1
File:Acute myeloid leukemia-M1 0003.jpg
Acute myeloid leukemia-M1


File:Acute myeloid leukemia-M2 0002.jpg
Acute myeloid leukemia-M2 - presence of granules can be noted
File:Acute myeloid leukemia-M2 0001.jpg
Acute myeloid leukemia-M2 - large myeloblasts with prominent nucleoli
File:Acute myeloid leukemia-M2 0004.jpg
Acute myeloid leukemia-M2 - maturing myeloid elements including band and segmented neutrophils in the background
File:Acute myeloid leukemia-M2 0003.jpg
Acute myeloid leukemia-M2 - presence of a few maturing myeloid elements


File:Acute myeloid leukemia-M3 0006.jpg
Acute myeloid leukemia-M3 - also called promyelocytic leukemia. Hypergranular morphology with most cells containing abundant large granules
File:Acute myeloid leukemia-M3 0004.jpg
Acute myeloid leukemia-M3 - ruptured cells are releasing their granules free onto the slide. Presence of Auer rods can be noticed
File:Acute myeloid leukemia-M3 0002.jpg
Acute myeloid leukemia-M3 - presence of abundant fine granules
File:Acute myeloid leukemia-M3 0001.jpg
Acute myeloid leukemia-M3 - polarity of cytoplasmic granulation. In many cells the granules tend to polarize toward one portion of the cytoplasm and the nucleus on the opposite side


File:Acute myeloid leukemia-M3 Auer bodies 0005.jpg
Acute myeloid leukemia-M3 Auer bodies
File:Acute myeloid leukemia-M3 Auer bodies 0003.jpg
Acute myeloid leukemia-M3 Auer bodies
File:Acute myeloid leukemia-M3 variation 0007.jpg
Acute myeloid leukemia-M3 variation
File:Acute myeloid leukemia-M4 0001.jpg
Acute myeloid leukemia-M4 - large monoblasts with abundant cytoplasm and moderately to intensely basophilic. The monoblasts will have lacy nuclear chromatin and one or more predominant nucleoli.


File:Acute myeloid leukemia-M5a 0003.jpg
Acute myeloid leukemia-M5a - >80% monoblasts in the marrow
File:Acute myeloid leukemia-M5a 0001.jpg
Acute myeloid leukemia-M5a - large monoblasts with fine nuclear chromatin and prominent nucleoli. Note the absence of Auer rods
File:Acute myeloid leukemia-M5a alpha naphtyle acetat 0002.jpg
Acute myeloid leukemia-M5a (alpha naphtyle acetat)
File:Acute myeloid leukemia-M5b 0001.jpg
Acute myeloid leukemia-M5b - <80% monoblasts in the marrow


File:Acute myeloid leukemia-M5b 0002.jpg
Acute myeloid leukemia-M5b - moderate amounts of cytoplasm and large nuclei with fine chromatin but without prominent nucleoli. Note presence of nuclear folds and creases, which are a characteristic feature of promonocytes.
File:Acute myeloid leukemia-M7 0001.jpg
Acute myeloid leukemia-M7 - irregular cytoplasmic border is often noted in some of the megakaryoblasts and occasionally projections resembling budding atypical platelets are present
File:Acute myeloid leukemia-M7 CD41 0001.jpg
Acute myeloid leukemia-M7 - megakaryoblasts are usually medium sized to large cells with a high nuclear-cytoplasmic ratio. Nuclear chromatin is dense and homogeneous

References

  1. Fialkow PJ: Clonal origin of human tumors. Biochim Biophys Acta 1976;458:283–321. PMID 1067873
  2. Fialkow PJ, Janssen JW, Bartram CR: Clonal remissions in acute nonlymphocytic leukemia: Evidence for a multistep pathogenesis of the malignancy. Blood 1991;77:1415–1517. PMID 2009365
  3. Bonnet D, Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730–737. PMID 9212098
  4. Abeloff, Martin et al. (2004), pp. 2831–32.
  5. Greer, John P., et al. Wintrobe's Clinical Hematology, 11th ed. Philadelphia: Lippincott, Williams, and Wilkins, 2004. p. 2045–2062
  6. Melnick A, Licht JD. Deconstructing a disease: RARα its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 1999;93:3167–3215. PMID 10233871
  7. Abeloff, Martin et al. (2004), p. 2828.

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