Pheochromocytoma pathophysiology: Difference between revisions
No edit summary |
No edit summary |
||
| Line 11: | Line 11: | ||
* Approximately 10% are familial | * Approximately 10% are familial | ||
* Approximately 10% recur after being resected | * Approximately 10% recur after being resected | ||
* Approximately 10% patients do not have [[hypertension]] (Campbell's Urology) | * Approximately 10% patients do not have [[hypertension]] (Campbell's Urology)These tumors can form a pattern with other endocrine gland cancers which is labeled [[multiple endocrine neoplasia]] (MEN). Pheochromocytoma may occur in patients with MEN 2 and MEN 3. [[VHL]] (Von Hippel Lindau) patients may also develop these tumors. | ||
===Tumor Location=== | ===Tumor Location=== | ||
In adults, 90% tumors are located unilaterally and are solitary, and 10% are located outside the adrenal gland. In children 50% are adrenal, while 25% are bilateral and 25% are extraadrenal. The common extradrenal locations are the abdomen, thorax and urinary bladder. | In adults, 90% tumors are located unilaterally and are solitary, and 10% are located outside the adrenal gland. In children 50% are adrenal, while 25% are bilateral and 25% are extraadrenal. The common extradrenal locations are the abdomen, thorax and urinary bladder. | ||
Revision as of 14:27, 2 September 2015
|
Pheochromocytoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Pheochromocytoma pathophysiology On the Web |
|
American Roentgen Ray Society Images of Pheochromocytoma pathophysiology |
|
Risk calculators and risk factors for Pheochromocytoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Traditionally it is known as the "10% tumor":
- bilateral disease is present in approximately 10% of patients
- approximately 10% of tumours are malignant
- approximately 10% are located in chromaffin tissue outside of the adrenal gland
- Approximately 10% arise in childhood
- Approximately 10% are familial
- Approximately 10% recur after being resected
- Approximately 10% patients do not have hypertension (Campbell's Urology)These tumors can form a pattern with other endocrine gland cancers which is labeled multiple endocrine neoplasia (MEN). Pheochromocytoma may occur in patients with MEN 2 and MEN 3. VHL (Von Hippel Lindau) patients may also develop these tumors.
Tumor Location
In adults, 90% tumors are located unilaterally and are solitary, and 10% are located outside the adrenal gland. In children 50% are adrenal, while 25% are bilateral and 25% are extraadrenal. The common extradrenal locations are the abdomen, thorax and urinary bladder.
Images
-
-
![Norepinephrine]]](/images/6/62/Norepinephrine.png)
-
Micrograph of pheochromocytoma.
-
Histopathology of adrenal pheochromocytoma. Adrenectomy specimen.
-
Micrograph of pheochromocytoma.
-
Micrograph of pheochromocytoma.
-
Bilateral pheochromocytoma in MEN2. Gross image.
![Norepinephrine]]](/index.php/File:Norepinephrine.png)
_histopathology.jpg)
_histopathology.jpg)
_histopathology.jpg)
