Acute lymphoblastic leukemia history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Carlos A Lopez, M.D. [3]

Overview

Symptoms of acute lymphoblastic leukemia include generalised weakness and fatigue, frequent or unexplained fever and infections, weight loss and/or loss of appetite, excessive bruising, bleeding from wounds, nosebleeds, petechiae, bone pain, joint pains and dyspnea.

Symptoms

Symptoms of acute lymphoblastic leukemia include the following:

• Generalised weakness and fatigue
• Anemia
• Frequent or unexplained fever and infections
• Weight loss
• Anorexia
• Excessive bruising
• Petechiae
• Excessive bleeding from minor wounds
• Epistaxis
• Bone pain
• Arthralgia (caused by the spread of "blast" cells to the surface of the bone or into the joint from the marrow cavity)
• Dyspnea

The symptoms of acute lymphoblastic leukemia result from the lack of normal and healthy blood cells because they are crowded out by malignant and immature leukocytes (white blood cells). Therefore, people with acute lymphoblastic leukemia experience symptoms from dysfunctional erythrocytes, leukocytes, and platelets.