Pheochromocytoma overview: Difference between revisions
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==Overview== | ==Overview== | ||
A '''pheochromocytoma''' ('''phaeochromocytoma''' outside of the US) is a [[neuroendocrine tumor]] of the [[Adrenal medulla|medulla]] of the [[adrenal gland]]s (originating in the [[chromaffin cell]]s) or extra-adrenal chromaffin tissue which failed to involute after birth,<ref>{{cite book |author=Boulpaep, Emile L.; Boron, Walter F. |title=Medical physiology: a cellular and molecular approach |publisher=Saunders |location=Philadelphia |year=2003 |pages=1065 |isbn=0-7216-3256-4 |oclc= |doi=}}</ref> which secretes excessive amounts of [[catecholamine]]s, usually [[epinephrine]] and [[norepinephrine]]. | A '''pheochromocytoma''' ('''phaeochromocytoma''' outside of the US) is a [[neuroendocrine tumor]] of the [[Adrenal medulla|medulla]] of the [[adrenal gland]]s (originating in the [[chromaffin cell]]s) or extra-adrenal chromaffin tissue which failed to involute after birth,<ref>{{cite book |author=Boulpaep, Emile L.; Boron, Walter F. |title=Medical physiology: a cellular and molecular approach |publisher=Saunders |location=Philadelphia |year=2003 |pages=1065 |isbn=0-7216-3256-4 |oclc= |doi=}}</ref> which secretes excessive amounts of [[catecholamine]]s, usually [[epinephrine]] and [[norepinephrine]]. | ||
Extra-adrenal [[paragangliomas]] (often described as extra-adrenal pheochromocytomas) are closely related, though less common, tumors that originate in the [[ganglion|ganglia]] of the [[sympathetic nervous system]] and are named based upon the primary anatomical site of origin. | Extra-adrenal [[paragangliomas]] (often described as extra-adrenal pheochromocytomas) are closely related, though less common, tumors that originate in the [[ganglion|ganglia]] of the [[sympathetic nervous system]] and are named based upon the primary anatomical site of origin. | ||
==Historical Perspective== | |||
In 1886, Fränkel made the first description of a patient with pheochromocytoma, however the term was first coined by Pick, a pathologist, in 1912. In 1926, Roux (in Switzerland) and Mayo (in U.S.A.) were the first surgeons to remove pheochromocytomas.<br /> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 19:45, 2 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
A pheochromocytoma (phaeochromocytoma outside of the US) is a neuroendocrine tumor of the medulla of the adrenal glands (originating in the chromaffin cells) or extra-adrenal chromaffin tissue which failed to involute after birth,[1] which secretes excessive amounts of catecholamines, usually epinephrine and norepinephrine. Extra-adrenal paragangliomas (often described as extra-adrenal pheochromocytomas) are closely related, though less common, tumors that originate in the ganglia of the sympathetic nervous system and are named based upon the primary anatomical site of origin.
Historical Perspective
In 1886, Fränkel made the first description of a patient with pheochromocytoma, however the term was first coined by Pick, a pathologist, in 1912. In 1926, Roux (in Switzerland) and Mayo (in U.S.A.) were the first surgeons to remove pheochromocytomas.
References
- ↑ Boulpaep, Emile L.; Boron, Walter F. (2003). Medical physiology: a cellular and molecular approach. Philadelphia: Saunders. p. 1065. ISBN 0-7216-3256-4.