Pheochromocytoma classification: Difference between revisions
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Pheochromocytoma can be either [[benign]] or [[malignant]] and can be localized, regional or [[metastatic]]. | Pheochromocytoma can be either [[benign]] or [[malignant]] and can be localized, regional or [[metastatic]]. | ||
==Classification== | ==Classification== | ||
Pheochromocytoma can be either [[benign]] or [[malignant]] and can be localized, regional or [[metastatic]]. | *Pheochromocytoma can be either [[benign]] or [[malignant]] and can be localized, regional or [[metastatic]]. | ||
*The most common sites of metastasis for pheochromocytoma are [[lymph nodes]], [[bones]], [[lungs]], and [[liver]]. | |||
The most common sites of metastasis for pheochromocytoma are [[lymph nodes]], [[bones]], [[lungs]], and [[liver]]. | *Pheochromocytoma is a [[tumor]] of the [[multiple endocrine neoplasia]] syndrome, type IIA (also known as MEN IIA) and type IIB MEN IIB. The other component [[neoplasms]] of that syndrome include [[parathyroid]] [[adenomas]], and [[medullary thyroid cancer]]. [[Mutations]] in the [[autosomal]] RET [[proto-oncogene]] drives these malignancies<ref>{{OMIM|171400|MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA; MEN2A}}</ref>. | ||
==References== | ==References== |
Revision as of 20:41, 2 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Pheochromocytoma can be either benign or malignant and can be localized, regional or metastatic.
Classification
- Pheochromocytoma can be either benign or malignant and can be localized, regional or metastatic.
- The most common sites of metastasis for pheochromocytoma are lymph nodes, bones, lungs, and liver.
- Pheochromocytoma is a tumor of the multiple endocrine neoplasia syndrome, type IIA (also known as MEN IIA) and type IIB MEN IIB. The other component neoplasms of that syndrome include parathyroid adenomas, and medullary thyroid cancer. Mutations in the autosomal RET proto-oncogene drives these malignancies[1].