Ganglioglioma pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
===Gross Pathology=== | ===Gross Pathology=== | ||
There is predilection towards the [[temporal lobes]]. | There is predilection towards the [[temporal lobes]].<ref name=dd>Pathophysiology of ganglioglioma. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioglioma</ref> | ||
===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
Gangliogliomas are composed of two cell populations: | Gangliogliomas are composed of two cell populations:<ref name=dd>Pathophysiology of ganglioglioma. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioglioma</ref> | ||
*Ganglion cells (large mature neuronal elements): ''ganglio-'' | *Ganglion cells (large mature neuronal elements): ''ganglio-'' | ||
*Neoplastic glial elements (primarily astrocytic): ''-glioma'' | *Neoplastic glial elements (primarily astrocytic): ''-glioma'' | ||
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===Markers=== | ===Markers=== | ||
Neuronal origin is demonstrated by positivity to neuronal markers: | Neuronal origin is demonstrated by positivity to neuronal markers:<ref name=dd>Pathophysiology of ganglioglioma. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioglioma</ref> | ||
*Synaptophysin | *Synaptophysin | ||
*Neuronal specific enolase | *Neuronal specific enolase | ||
Revision as of 14:53, 3 September 2015
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Ganglioglioma Microchapters |
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Diagnosis |
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Ganglioglioma pathophysiology On the Web |
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Risk calculators and risk factors for Ganglioglioma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathophysiology
Gross Pathology
There is predilection towards the temporal lobes.[1]
Microscopic Pathology
Gangliogliomas are composed of two cell populations:[1]
- Ganglion cells (large mature neuronal elements): ganglio-
- Neoplastic glial elements (primarily astrocytic): -glioma
It is the grade of the glial component that determines biological behaviour. Dedifferentiation into high grade tumours does occasionally occur, and it is usually the glial component (into a glioblastoma multiforme). Only rarely is it the neuronal component (into a neuroblastoma).
Markers
Neuronal origin is demonstrated by positivity to neuronal markers:[1]
- Synaptophysin
- Neuronal specific enolase
- GFAP marker
References
- ↑ 1.0 1.1 1.2 Pathophysiology of ganglioglioma. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioglioma