Vaginal cancer pathophysiology

Vaginal cancer Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

On gross pathology, an ulcerating or fungating mass , or an annular constricting lesion is characteristic finding of vaginal cancer.

Pathophysiology

Lesions characteristically arise from the posterior wall of the upper third of the vagina. The common patterns of disease are:

• an ulcerating or fungating mass or
• an annular constricting lesion

Vaginal squamous cell carcinoma arises from the thin, flat squamous cells that line the vagina. Vaginal adenocarcinoma arises from the glandular (secretory) cells in the lining of the vagina that produce some vaginal fluids.