Ganglioglioma pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
===Gross Pathology=== | ===Gross Pathology=== | ||
There is predilection towards the [[temporal lobes]]<ref name=dd>Pathophysiology of ganglioglioma. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioglioma</ref> | *There is predilection towards the [[temporal lobes]]<ref name=dd>Pathophysiology of ganglioglioma. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioglioma</ref> | ||
*Other parts where ganglioglioma can occur include: | |||
**[[Frontal lobe]] | |||
**[[Parietal lobe]] | |||
**[[Occipital lobe]] | |||
**[[Thalamus]] | |||
**[[Third ventricle]] | |||
**[[Spinal cord]]. | |||
*Their appearance is very variable: from a partially cystic mass with an mural nodule (~45% of cases) to a solid mass expanding the overlying gyrus. | |||
===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
Revision as of 13:26, 4 September 2015
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Risk calculators and risk factors for Ganglioglioma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathophysiology
Gross Pathology
- There is predilection towards the temporal lobes[1]
- Other parts where ganglioglioma can occur include:
- Their appearance is very variable: from a partially cystic mass with an mural nodule (~45% of cases) to a solid mass expanding the overlying gyrus.
Microscopic Pathology
Gangliogliomas are composed of two cell populations:[1]
- Ganglion cells (large mature neuronal elements): ganglio-
- Neoplastic glial elements (primarily astrocytic): -glioma
It is the grade of the glial component that determines biological behaviour. Dedifferentiation into high grade tumours does occasionally occur, and it is usually the glial component (into a glioblastoma multiforme). Only rarely is it the neuronal component (into a neuroblastoma).
Markers
Neuronal origin is demonstrated by positivity to neuronal markers:[1]
- Synaptophysin
- Neuronal specific enolase
- GFAP
References
- ↑ 1.0 1.1 1.2 Pathophysiology of ganglioglioma. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioglioma