Retinoblastoma causes: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 2: | Line 2: | ||
{{Retinoblastoma}} | {{Retinoblastoma}} | ||
==Overview== | ==Overview== | ||
*'''Retinoblastoma''' is a [[cancer]] of the [[retina]]. Development of this tumor is initiated by [[mutation]]s | *'''Retinoblastoma''' is a [[cancer]] of the [[retina]]. Development of this tumor is initiated by [[mutation]]s that inactivate both copies of the ''[[RB1]]'' gene, which codes for the [[retinoblastoma protein]]. In children with the heritable genetic form of retinoblastoma there is a mutation on chromosome 13, called the RB1 gene. | ||
==Causes== | ==Causes== | ||
*Retinoblastoma is caused by a mutation in a gene controlling cell division, causing cells to grow out of control and become cancerous. | *Retinoblastoma is caused by a mutation in a gene controlling cell division, causing cells to grow out of control and become cancerous. | ||
Revision as of 15:05, 4 September 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
|
Retinoblastoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Retinoblastoma causes On the Web |
|
American Roentgen Ray Society Images of Retinoblastoma causes |
Overview
- Retinoblastoma is a cancer of the retina. Development of this tumor is initiated by mutations that inactivate both copies of the RB1 gene, which codes for the retinoblastoma protein. In children with the heritable genetic form of retinoblastoma there is a mutation on chromosome 13, called the RB1 gene.
Causes
- Retinoblastoma is caused by a mutation in a gene controlling cell division, causing cells to grow out of control and become cancerous.
- In a little over half of the cases, this mutation develops in a child whose family has never had eye cancer.
- Other times the mutation is present in several family members. If the mutation runs in the family, there is a 50% chance that an affected person's children will also have the mutation. They will therefore have a high risk of developing retinoblastoma themselves.
- The cancer generally affects children under the age of 6. It is most commonly diagnosed in children aged 1 - 2 years.
References