Retinoblastoma causes: Difference between revisions
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{{Retinoblastoma}} | {{Retinoblastoma}} | ||
==Overview== | ==Overview== | ||
*'''Retinoblastoma''' is a [[cancer]] of the [[retina | *'''Retinoblastoma''' is a [[cancer]] of the [[retina]]. In children with the heritable genetic form of retinoblastoma there is a mutation on chromosome 13, called the RB1 gene.The defective RB1 gene can be inherited from either parent; in some children, however, the mutation occurs in the early stages of fetal development. Inheritance is autosomal dominant with 90% penetrance. | ||
==Causes== | ==Causes== | ||
Revision as of 15:07, 4 September 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Retinoblastoma Microchapters |
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Retinoblastoma causes On the Web |
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Overview
- Retinoblastoma is a cancer of the retina. In children with the heritable genetic form of retinoblastoma there is a mutation on chromosome 13, called the RB1 gene.The defective RB1 gene can be inherited from either parent; in some children, however, the mutation occurs in the early stages of fetal development. Inheritance is autosomal dominant with 90% penetrance.
Causes
- Retinoblastoma is caused by a mutation in a gene controlling cell division, causing cells to grow out of control and become cancerous.
- In a little over half of the cases, this mutation develops in a child whose family has never had eye cancer.
- Other times the mutation is present in several family members. If the mutation runs in the family, there is a 50% chance that an affected person's children will also have the mutation. They will therefore have a high risk of developing retinoblastoma themselves.
- The cancer generally affects children under the age of 6. It is most commonly diagnosed in children aged 1 - 2 years.
References