Retinoblastoma pathophysiology: Difference between revisions
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===Morphology=== | ===Morphology=== | ||
==Gross appearance | ==Gross appearance== | ||
: Gross and microscopic appearances of retinoblastoma are identical in both hereditary and sporadic types. Macroscopically, viable tumor cells are found near blood vessels, while zones of necrosis are found in relatively avascular areas. | : Gross and microscopic appearances of retinoblastoma are identical in both hereditary and sporadic types. Macroscopically, viable tumor cells are found near blood vessels, while zones of necrosis are found in relatively avascular areas. | ||
==Microscopic appearance== | ==Microscopic appearance== | ||
: Microscopically, both undifferentiated and differentiated elements may be present. Undifferentiated elements appear as collections of small, round cells with hyperchromatic nuclei; differentiated elements include Flexner-Wintersteiner rosettes, Homer-Wright rosettes and fluerettes from photoreceptor differentiation. | : Microscopically, both undifferentiated and differentiated elements may be present. Undifferentiated elements appear as collections of small, round cells with hyperchromatic nuclei; differentiated elements include Flexner-Wintersteiner rosettes, Homer-Wright rosettes and fluerettes from photoreceptor differentiation. | ||
Revision as of 18:42, 4 September 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Retinoblastoma Microchapters |
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Diagnosis |
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Treatment |
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Retinoblastoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Retinoblastoma pathophysiology |
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Risk calculators and risk factors for Retinoblastoma pathophysiology |
Overview
Morphology
Gross appearance
- Gross and microscopic appearances of retinoblastoma are identical in both hereditary and sporadic types. Macroscopically, viable tumor cells are found near blood vessels, while zones of necrosis are found in relatively avascular areas.
Microscopic appearance
- Microscopically, both undifferentiated and differentiated elements may be present. Undifferentiated elements appear as collections of small, round cells with hyperchromatic nuclei; differentiated elements include Flexner-Wintersteiner rosettes, Homer-Wright rosettes and fluerettes from photoreceptor differentiation.