Hodgkin's lymphoma epidemiology and demographics: Difference between revisions
No edit summary |
|||
| Line 23: | Line 23: | ||
===Gender=== | ===Gender=== | ||
* In children <5 year, | * In children <5 year, males are more commonly affected with Hodgkin's lymphoma than females. The male to female ratio is approximately 5.3. | ||
* In children aged 15 to 19 year, | * In children aged 15 to 19 year, females are more commonly affected with Hodgkin's lymphoma than males. The male to female ratio is approximately 0.8. | ||
Revision as of 14:50, 8 September 2015
|
Hodgkin's lymphoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Hodgkin's lymphoma epidemiology and demographics On the Web |
|
American Roentgen Ray Society Images of Hodgkin's lymphoma epidemiology and demographics |
|
Hodgkin's lymphoma epidemiology and demographics in the news |
|
Risk calculators and risk factors for Hodgkin's lymphoma epidemiology and demographics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
Overview
Unlike some other lymphomas, whose incidence increases with age, Hodgkin's lymphoma has a bimodal incidence curve; that is, it occurs most frequently in two separate age groups, the first being young adulthood (age 15–35) and the second being in those over 55 years old although these peaks may vary slightly with nationality.[1][2] In 2011, the age-adjusted incidence of Hodgkin's lymphoma was 2.71 per 100,000 persons in the United States.[3] The incidence of Hodgkin's lymphoma is higher among patients with HIV/AIDS; however, in contrast to many other lymphomas associated with HIV infection, Hodgkin's lymphoma occurs most commonly in patients who do not have severe immunosupression.[4] Reports from countries like Honduras,[5] China,[6] Mexico,[7] Peru,[8] and Malaysia[9] suggest an association between EBV infection and Hodgkin's lymphoma, an association that is more evident in the pediatric population[10] and in the subtype of mixed cellularity.[11]
Epidemiology and Demographics
Prevalence
- In the United States, the age-adjusted prevalence of Hodgkin's lymphoma is 35 per 100,000 in 2011.[3]
Incidence
In 2015, the incidence of Hodgkins lymphoma was estimated to be 3 cases per 100,000 individuals in the United States.
Age
- While the overall age-adjusted incidence of Hodgkin's lymphoma in the United States between 2007 and 2011 is 2.7 per 100,000, the age-adjusted incidence of Hodgkin's lymphoma by age category is:[3]
- Between 20 and 29 years: 4.1-4,5 per 100,000
- Under 65 years: 2.5 per 100,000
- 65 and over: 4.2 per 100,000
Gender
- In children <5 year, males are more commonly affected with Hodgkin's lymphoma than females. The male to female ratio is approximately 5.3.
- In children aged 15 to 19 year, females are more commonly affected with Hodgkin's lymphoma than males. The male to female ratio is approximately 0.8.
- In the United States, the age-adjusted prevalence of Hodgkin's lymphoma by gender in 2011 is:[3]
- In males: 37.2 per 100,000
- In females: 33.1 per 100,000
- In the United States, the delay-adjusted incidence of Hodgkin's lymphoma by gender in 2011 is:[3]
- In males: 3.22 per 100,000 persons
- In females: 2.42 per 100,000 persons
- In the United States, the age-adjusted incidence of Hodgkin's lymphoma by gender on 2011 is:[3]
- In males: 3.11 per 100,000 persons
- In females: 2.34 per 100,000 persons
Shown below is an image depicting the delay-adjusted incidence and observed incidence of Hodgkin's lymphoma by gender and race in the United States between 1975 and 2011. These graphs are adapted from SEER: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.[3]
Race
- Shown below is a table depicting the age-adjusted prevalence of Hodgkin's lymphoma by race in 2011 in the United States.[3]
| All Races | White | Black | Asian/Pacific Islander | Hispanic | |
| Age-adjusted prevalence | 35 per 100,000 | 40 per 100,000 | 32.1 per 100,000 | 12.6 per 100,000 | 23.6 per 100,000 |
Shown below is an image depicting the incidence of Hodgkin's lymphoma by race in the United States between 1975 and 2011.[3]
API: Asian/Pacific Islander; AI/AN: American Indian/ Alaska Native
References
- ↑ MacMahon B (1966). "Epidemiology of Hodgkin's disease". Cancer Res. 26 (6): 1189–201. PMID 5329907.
- ↑ Grufferman S, Delzell E (1984). "Epidemiology of Hodgkin's disease". Epidemiol Rev. 6: 76–106. PMID 6092122.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.
- ↑ Biggar RJ, Jaffe ES, Goedert JJ, Chaturvedi A, Pfeiffer R, Engels EA (2006). "Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS". Blood. 108 (12): 3786–91. doi:10.1182/blood-2006-05-024109. PMID 16917006.
- ↑ Ambinder RF, Browning PJ, Lorenzana I, Leventhal BG, Cosenza H, Mann RB; et al. (1993). "Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the United States". Blood. 81 (2): 462–7. PMID 8380725.
- ↑ Zhou XG, Hamilton-Dutoit SJ, Yan QH, Pallesen G (1993). "The association between Epstein-Barr virus and Chinese Hodgkin's disease". Int J Cancer. 55 (3): 359–63. PMID 8397160.
- ↑ Zarate-Osorno A, Roman LN, Kingma DW, Meneses-Garcia A, Jaffe ES (1995). "Hodgkin's disease in Mexico. Prevalence of Epstein-Barr virus sequences and correlations with histologic subtype". Cancer. 75 (6): 1360–6. PMID 7882287.
- ↑ Chang KL, Albújar PF, Chen YY, Johnson RM, Weiss LM (1993). "High prevalence of Epstein-Barr virus in the Reed-Sternberg cells of Hodgkin's disease occurring in Peru". Blood. 81 (2): 496–501. PMID 8380728.
- ↑ Peh SC, Looi LM, Pallesen G (1997). "Epstein-Barr virus (EBV) and Hodgkin's disease in a multi-ethnic population in Malaysia". Histopathology. 30 (3): 227–33. PMID 9088951.
- ↑ Armstrong AA, Alexander FE, Paes RP, Morad NA, Gallagher A, Krajewski AS; et al. (1993). "Association of Epstein-Barr virus with pediatric Hodgkin's disease". Am J Pathol. 142 (6): 1683–8. PMC 1886981. PMID 8389527.
- ↑ Andriko JA, Aguilera NS, Nandedkar MA, Abbondanzo SL (1997). "Childhood Hodgkin's disease in the United States: an analysis of histologic subtypes and association with Epstein-Barr virus". Mod Pathol. 10 (4): 366–71. PMID 9110300.