Ganglioneuroma pathophysiology: Difference between revisions
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*Ganglioneuromas are fully differentiated neuronal tumors that do ''not'' contain immature elements. | *Ganglioneuromas are fully differentiated neuronal tumors that do ''not'' contain immature elements. | ||
*They are composed of [[ganglion cells]], [[schwann cells]] and [[fibrous tissue]]. | *They are composed of [[ganglion cells]], [[schwann cells]] and [[fibrous tissue]]. | ||
*Histopathology consists of spindled cells, with cell borders in a fibrillar matrix, which contain ganglion cells, with large round nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. No atypia or mitotic activity was evident. The ganglion cells stained positive for S-100 protein. | |||
====Videos==== | ====Videos==== | ||
{{#ev:youtube|IWng6E9flDA}} | {{#ev:youtube|IWng6E9flDA}} | ||
== References == | == References == | ||
Revision as of 19:21, 9 September 2015
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Ganglioneuroma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Ganglioneuroma pathophysiology On the Web |
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American Roentgen Ray Society Images of Ganglioneuroma pathophysiology |
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Risk calculators and risk factors for Ganglioneuroma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathophysiology
Genetics
Development of ganglioneuroma is the result of multiple genetic mutations. Genes involved in the pathogenesis of ganglioneuroma include MYCN oncogene and chromosome 1p36.
Associated Conditions
- Multiple endocrine neoplasia type IIb: particularly with mucosal ganglioneuromas.[1]
- Turner syndrome
- Neurofibromatosis type 1
Gross Pathology
- Ganglioneuromas are solid, firm tumors that are typically white when seen with the naked eye
- Gangliocytoma is commonly located in the following regions:[1]
- Posterior paraspinal mediastinum (most common)
- Adrenal gland
- Paraspinal retroperitoneum
- Neck
Microscopic Pathology
- Ganglioneuromas are derived from the primordial neural crest cells, which are undifferentiated cells of the sympathetic nervous system.
- Ganglioneuromas are fully differentiated neuronal tumors that do not contain immature elements.
- They are composed of ganglion cells, schwann cells and fibrous tissue.
- Histopathology consists of spindled cells, with cell borders in a fibrillar matrix, which contain ganglion cells, with large round nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. No atypia or mitotic activity was evident. The ganglion cells stained positive for S-100 protein.
Videos
{{#ev:youtube|IWng6E9flDA}}
References
- ↑ 1.0 1.1 Pathology of ganglioneuroma. Dr Bruno Di Muzio and Dr Yuranga Weerakkody et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioneuroma