Ganglioneuroma overview: Difference between revisions
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==Differentiating brain tumors from other diseases== | ==Differentiating brain tumors from other diseases== | ||
Ganglioglioma must be differentiated from neuroblastoma, ganglioneuroblastoma, spinal [[schwannoma]], spinal [[neurofibroma]], [[adrenal adenoma]], [[adrenal carcinoma]], and [[pheochromocytoma]].<ref name=ddd>D.Dx of ganglioneuroma. Dr Bruno Di Muzio and Dr Yuranga Weerakkody et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioneuroma</ref><ref name=staging>{{cite journal |last=Adam |first=O |last2=Boia |first2=ES |date=2007 |title=ganglioneuroma |url=http://www.jurnalulpediatrului.ro/pages/arhiva/39-40/39-40-IV-11.pdf |journal=jurnalul pediatrului |publisher= |volume=10 |issue=39-40|doi= |access-date=10 September 2015}}</ref> | Ganglioglioma must be differentiated from [[neuroblastoma]], [[ganglioneuroblastoma]], spinal [[schwannoma]], spinal [[neurofibroma]], [[adrenal adenoma]], [[adrenal carcinoma]], and [[pheochromocytoma]].<ref name=ddd>D.Dx of ganglioneuroma. Dr Bruno Di Muzio and Dr Yuranga Weerakkody et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioneuroma</ref><ref name=staging>{{cite journal |last=Adam |first=O |last2=Boia |first2=ES |date=2007 |title=ganglioneuroma |url=http://www.jurnalulpediatrului.ro/pages/arhiva/39-40/39-40-IV-11.pdf |journal=jurnalul pediatrului |publisher= |volume=10 |issue=39-40|doi= |access-date=10 September 2015}}</ref> | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Revision as of 18:12, 11 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Classification
According to International Neuroblastoma Pathology Classification (INPC), ganglioneuroma may be classified into two subtypes/groups: Ganglioneuroma-maturing and ganglioneuroma-mature.[1]
Pathophysiology
On gross pathology, ganglioneuromas are characterized by solid, white, firm, well-circumscribed, and nodular tumors. On microscopic histopathological analysis, ganglioneuromas are characterized by spindle-shaped cells with cell borders in a fibrillar matrix containing ganglion cells with large round nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm.[2] Genes involved in the pathogenesis of ganglioneuroma include MYCN oncogene and chromosome 1p36.
Causes
There are no established causes for ganglioneuroma.[3]
Differentiating brain tumors from other diseases
Ganglioglioma must be differentiated from neuroblastoma, ganglioneuroblastoma, spinal schwannoma, spinal neurofibroma, adrenal adenoma, adrenal carcinoma, and pheochromocytoma.[3][4]
Epidemiology and Demographics
Risk factors
Natural History, Complications and Prognosis
Diagnosis
Staging
History and Symptoms
Physical examination
Laboratory Findings
X Ray
CT
MRI
Ultrasound
Other imaging findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
References
- ↑ Okamatsu C, London WB, Naranjo A, Hogarty MD, Gastier-Foster JM, Look AT; et al. (2009). "Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG". Pediatr Blood Cancer. 53 (4): 563–9. doi:10.1002/pbc.22106. PMC 2730988. PMID 19530234.
- ↑ Vasiliadis K, Papavasiliou C, Fachiridis D, Pervana S, Michaelides M, Kiranou M; et al. (2012). "Retroperitoneal extra-adrenal ganglioneuroma involving the infrahepatic inferior vena cava, celiac axis and superior mesenteric artery: A case report". Int J Surg Case Rep. 3 (11): 541–3. doi:10.1016/j.ijscr.2012.07.008. PMC 3437388. PMID 22907039.
- ↑ 3.0 3.1 Causes for ganglioneuroma. National Library of Meidicine. https://www.nlm.nih.gov/medlineplus/ency/article/001437.htm
- ↑ Adam, O; Boia, ES (2007). "ganglioneuroma" (PDF). jurnalul pediatrului. 10 (39–40). Retrieved 10 September 2015.