Acoustic neuroma pathophysiology: Difference between revisions
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Revision as of 14:39, 14 September 2015
Acoustic neuroma Microchapters | |
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Acoustic neuroma pathophysiology On the Web | |
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Risk calculators and risk factors for Acoustic neuroma pathophysiology | |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
On microscopic histopathological analysis, acoustic neuroma is characterized into two types, Antoni A and Antoni B, based on growth patterns.
Pathophysiology
Acoustic schwannomas are benign tumours (WHO grade 1), which usually arise from the intracanalicular segment of the vestibular portion of the vestibulocochlear nerve (CN VIII), near the transition point between glial and Schwann cells (Obersteiner-Redlich zone) 8. In over 90% of cases these tumors arise from the inferior division of the vestibular nerve 8. They are well circumscribed encapsulated masses, which unlike neuromas, arise from but are separate from nerve fibers 7, which they usually splay and displace rather than incorporated.
Microscopic Pathology
They can display two types of growth pattern:
- Antoni A
- Elongated cells with cytoplasmic processes arranged in fascicles 7.
- Little stromal matrix.
- Verocay bodies: nuclear free zones of processes lying between regions of nuclear palisading.
- Antoni B
- Loose meshwork of cells.
- Less densely cellular.
- Microcysts and myxoid change.