Multiple myeloma history and symptoms: Difference between revisions
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==Common Symptoms== | ==Common Symptoms== | ||
:*[[Bone pain]] | :*[[Bone pain]] | ||
:* | ::*Usually involves the spine and ribs, and worsens with activity. | ||
:*[[Numbness]] | ::*Persistent localized pain may indicate a pathological [[bone fracture]] | ||
:*[[Confusion]] | :*Neurological symptoms | ||
:*[[Dizziness]] | ::*[[Numbness]] | ||
::*[[muscle weakness]] | |||
::*[[Confusion]] | |||
::*[[Dizziness]] | |||
::*[[Headache]] | |||
::*visual changes | |||
:*[[Edema]] in legs | :*[[Edema]] in legs | ||
:* Bleeding | :* Bleeding | ||
:* Recurrent infections | :* Recurrent infections | ||
::*The most common infections are [[pneumonia]]s and [[pyelonephritis]]. | |||
==References== | ==References== | ||
Revision as of 15:55, 17 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The presenting symptoms of multiple myeloma may vary greatly due to involvement of many organ systems. A mnemonic sometimes used to remember the common tetrad of multiple myeloma is CRAB - C = Calcium (elevated), R =Renal failure, A = Anemia, B = Bone lesions.[1]
History
- Early multiple myeloma does not have any symptoms.
- In as many as 30-40% cases the diagnosis may be incidental and is often diagnosed on routine blood screening.
- A rise in total protein levels without a concomitant rise in albumin levels must make the physician suspicious for a possibility of multiple myeloma.
- As the tumor grows larger people may notice one or more of the symptoms.
Common Symptoms
-
- Usually involves the spine and ribs, and worsens with activity.
- Persistent localized pain may indicate a pathological bone fracture
- Neurological symptoms
- Numbness
- muscle weakness
- Confusion
- Dizziness
- Headache
- visual changes
- Edema in legs
- Bleeding
- Recurrent infections
- The most common infections are pneumonias and pyelonephritis.
References
- ↑ International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121:749-57. PMID 12780789.