Vulvar cancer pathophysiology: Difference between revisions
No edit summary |
|||
| Line 22: | Line 22: | ||
Low grade pre-cancerous lesions (VIN) are typically HPV positive, while high grade pre-cancerous lesions and cancer are less often HPV positive.[13] | Low grade pre-cancerous lesions (VIN) are typically HPV positive, while high grade pre-cancerous lesions and cancer are less often HPV positive.[13] | ||
===Microscopic=== | |||
Like SCC elsewhere. | Like SCC elsewhere. | ||
Microinvasion: <=1 mm stromal invasion, tumour size <=2 cm (T1a).[14] | Microinvasion: <=1 mm stromal invasion, tumour size <=2 cm (T1a).[14] | ||
Revision as of 14:21, 18 September 2015
|
Vulvar cancer Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Vulvar cancer pathophysiology On the Web |
|
American Roentgen Ray Society Images of Vulvar cancer pathophysiology |
|
Risk calculators and risk factors for Vulvar cancer pathophysiology |
Malignant neoplasms of the vulva
Overview
Most common malignancies of vulva: Invasive squamous cell carcinoma. Malignant melanoma.
Vulvar squamous cell carcinoma
General
Most common vulvar malignancy. Precursor lesions for SCC Vulvar intraepithelial neoplasia (VIN). VIN can be divided into: Classic VIN, and Differentiated VIN. Differentiated VIN is mostly irrelevant as it is basically never seen alone, i.e. it usually accompanies cancer. Low grade pre-cancerous lesions (VIN) are typically HPV positive, while high grade pre-cancerous lesions and cancer are less often HPV positive.[13]
Microscopic
Like SCC elsewhere. Microinvasion: <=1 mm stromal invasion, tumour size <=2 cm (T1a).[14] Depth from DE junction.
Note:
Tumour thickness != depth of invasion. Thickness = granular layer or surface (no granular layer present) to deepest tumour. Depth of invasion = epithelial-stromal junction in "valley" of papillae.
DDx:
Classic vulvar intraepithelial neoplasia - esp. tangential sections. Differentiated vulvar intraepithelial neoplasia.
Sign out
VULVA, LEFT SIDE, (INCISIONAL) BIOPSY: - INVASIVE SQUAMOUS CELL CARCINOMA. -- PLEASE SEE TUMOUR SUMMARY.
TUMOUR SUMMARY - VULVA Specimen Size: multiple fragments - up to 2.5 cm in aggregate. Tumour site: left vulva - around Bartholin's gland. Tumour size: at least 10 mm, cannot be determined due to fragmentation. Tumour focality: cannot be determined. Histologic type: squamous cell carcinoma with focal keratinization. Histologic Grade: G2 - moderately differentiated. Microscopic tumour extension: greater than 2 mm, assessment limited by
fragmentation and tissue orientation.
Tumour border: infiltrating. Lymph-Vascular Invasion: present. Additional findings:
Vulvar intraepithelial neoplasia (VIN) 3 (severe dysplasia/carcinoma in situ).