DRESS syndrome diagnostic criteria: Difference between revisions
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__NOTOC__ | |||
{{DRESS syndrome}} | |||
{{CMG}}; {{AE}} | |||
==Overview== | |||
==Diagnostic Criteria== | |||
*There is no gold standard for the diagnosis of DRESS syndome. | |||
*Two diagnostic criteria have been proposed: | |||
:*The RegiSCAR criteria <ref name=Kardaun>{{cite journal |vauthors=Kardaun SH, Sidoroff A, Valeyrie-Allanore L, etal |title=Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? |journal=Response Br J Dermatol |volume=156 |pages=609–610 |year=2007 |pmid=17300272 |doi=10.1111/j.1365-2133.2006.07704.x |issue=3 }}</ref> | |||
:*The Japanese consensus group criteria<ref name=Shiohara>{{cite journal |author=Shiohara T, Iijima M, Ikezawa Z, Hashimoto K. |title=The diagnosis of DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations|journal=Response Br J Dermatol |volume=156 |pages=1045–92 |year=2007 |pmid=17381452 |issue=5 |doi=10.1111/j.1365-2133.2007.07807.x }}</ref> are detailed in the table below. | |||
{| class="wikitable" | {| class="wikitable" | ||
|- | |- | ||
! RegiSCAR inclusion criteria for DRESS syndrome. | ! RegiSCAR inclusion criteria for DRESS syndrome. At least three of the four starred criteria are required for diagnosis !! Japanese consensus group diagnostic criteria for DIHS. Seven criteria needed for the diagnosis of DRESS syndrome or the first five criteria required for diagnosis of atypical DIHS | ||
|- | |- | ||
| Hospitalization || Maculopapular rash | | Hospitalization || Maculopapular rash > 3 weeks following administration of drug | ||
|- | |- | ||
| Reaction suspected to be drug-related || Prolonged clinical symptoms 2 weeks | | Reaction suspected to be drug-related || Prolonged clinical symptoms 2 weeks following the discontinuation of the suspected drug | ||
|- | |- | ||
| Acute Rash*|| Fever > 38 °C | | Acute Rash*|| Fever > 38 °C | ||
|- | |- | ||
| Fever > 38 °C* || Liver abnormalities (ALT > 100 U/L) or other organ involvement | | Fever > 38 °C* || Liver function test abnormalities (ALT > 100 U/L) or other organ involvement | ||
|- | |- | ||
| [[Lymphadenopathy]] in at least two sites* || [[Leukocyte]] abnormalities | | [[Lymphadenopathy]] in at least two sites* || [[Leukocyte]] abnormalities | ||
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| || [[Human herpesvirus 6]] reactivation | | || [[Human herpesvirus 6]] reactivation | ||
|} | |} | ||
==References== | |||
{{Reflist|2}} | |||
[[Category:Syndromes]] | |||
[[Category:Skin diseases]] | |||
[[Category:Dermatology]] | |||
[[Category:Hematology]] | |||
[[Category:Hepatology]] | |||
[[Category:Medicine]] | |||
Revision as of 13:40, 21 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Diagnostic Criteria
- There is no gold standard for the diagnosis of DRESS syndome.
- Two diagnostic criteria have been proposed:
| RegiSCAR inclusion criteria for DRESS syndrome. At least three of the four starred criteria are required for diagnosis | Japanese consensus group diagnostic criteria for DIHS. Seven criteria needed for the diagnosis of DRESS syndrome or the first five criteria required for diagnosis of atypical DIHS |
|---|---|
| Hospitalization | Maculopapular rash > 3 weeks following administration of drug |
| Reaction suspected to be drug-related | Prolonged clinical symptoms 2 weeks following the discontinuation of the suspected drug |
| Acute Rash* | Fever > 38 °C |
| Fever > 38 °C* | Liver function test abnormalities (ALT > 100 U/L) or other organ involvement |
| Lymphadenopathy in at least two sites* | Leukocyte abnormalities |
| Involvement of at least one internal organ* | Leukocytosis ( > 11 x 109/L) |
| Blood count abnormalities (lymphopenia or lymphocytosis*, eosinophilia*, thrombocytopenia*) | Atypical lymphocytosis (>5%) |
| Lymphadenopathy | |
| Human herpesvirus 6 reactivation |
References
- ↑ Kardaun SH, Sidoroff A, Valeyrie-Allanore L, et al. (2007). "Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?". Response Br J Dermatol. 156 (3): 609–610. doi:10.1111/j.1365-2133.2006.07704.x. PMID 17300272.
- ↑ Shiohara T, Iijima M, Ikezawa Z, Hashimoto K. (2007). "The diagnosis of DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations". Response Br J Dermatol. 156 (5): 1045–92. doi:10.1111/j.1365-2133.2007.07807.x. PMID 17381452.