DRESS syndrome diagnostic criteria: Difference between revisions
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==Overview== | ==Overview== | ||
==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
*There is no gold standard for the diagnosis of DRESS | *There is no gold standard for the diagnosis of DRESS syndrome. | ||
*Two diagnostic criteria have been proposed: | *Two diagnostic criteria have been proposed: | ||
:*The RegiSCAR criteria <ref name=Kardaun>{{cite journal |vauthors=Kardaun SH, Sidoroff A, Valeyrie-Allanore L, etal |title=Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? |journal=Response Br J Dermatol |volume=156 |pages=609–610 |year=2007 |pmid=17300272 |doi=10.1111/j.1365-2133.2006.07704.x |issue=3 }}</ref> | :*The RegiSCAR criteria <ref name=Kardaun>{{cite journal |vauthors=Kardaun SH, Sidoroff A, Valeyrie-Allanore L, etal |title=Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? |journal=Response Br J Dermatol |volume=156 |pages=609–610 |year=2007 |pmid=17300272 |doi=10.1111/j.1365-2133.2006.07704.x |issue=3 }}</ref> | ||
:*The Japanese consensus group criteria<ref name=Shiohara>{{cite journal |author=Shiohara T, Iijima M, Ikezawa Z, Hashimoto K. |title=The diagnosis of DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations|journal=Response Br J Dermatol |volume=156 |pages=1045–92 |year=2007 |pmid=17381452 |issue=5 |doi=10.1111/j.1365-2133.2007.07807.x }}</ref> | :*The Japanese consensus group criteria<ref name=Shiohara>{{cite journal |author=Shiohara T, Iijima M, Ikezawa Z, Hashimoto K. |title=The diagnosis of DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations|journal=Response Br J Dermatol |volume=156 |pages=1045–92 |year=2007 |pmid=17381452 |issue=5 |doi=10.1111/j.1365-2133.2007.07807.x }}</ref> | ||
The following table illustrates the diagnostic criteria for the diagnosis of DRESS syndrome based on the RegiSCAR criteria and the Japanese consensus group criteria: | |||
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Revision as of 13:42, 21 September 2015
DRESS syndrome Microchapters |
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DRESS syndrome On the Web |
American Roentgen Ray Society Images of DRESS syndrome |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Diagnostic Criteria
- There is no gold standard for the diagnosis of DRESS syndrome.
- Two diagnostic criteria have been proposed:
The following table illustrates the diagnostic criteria for the diagnosis of DRESS syndrome based on the RegiSCAR criteria and the Japanese consensus group criteria:
RegiSCAR inclusion criteria for DRESS syndrome. At least three of the four starred criteria are required for diagnosis |
Japanese consensus group diagnostic criteria for DIHS. Seven criteria needed for the diagnosis of DRESS syndrome or the first five criteria required for diagnosis of atypical DIHS |
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Hospitalization | Maculopapular rash > 3 weeks following administration of drug |
Reaction suspected to be drug-related | Prolonged clinical symptoms 2 weeks following the discontinuation of the suspected drug |
Acute Rash* | Fever > 38 °C |
Fever > 38 °C* | Liver function test abnormalities (ALT > 100 U/L) or other organ involvement |
Lymphadenopathy in at least two sites* | Leukocyte abnormalities |
Involvement of at least one internal organ* | Leukocytosis ( > 11 x 109/L) |
Blood count abnormalities (lymphopenia or lymphocytosis*, eosinophilia*, thrombocytopenia*) | Atypical lymphocytosis (>5%) |
Lymphadenopathy | |
Human herpesvirus 6 reactivation |
References
- ↑ Kardaun SH, Sidoroff A, Valeyrie-Allanore L, et al. (2007). "Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?". Response Br J Dermatol. 156 (3): 609–610. doi:10.1111/j.1365-2133.2006.07704.x. PMID 17300272.
- ↑ Shiohara T, Iijima M, Ikezawa Z, Hashimoto K. (2007). "The diagnosis of DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations". Response Br J Dermatol. 156 (5): 1045–92. doi:10.1111/j.1365-2133.2007.07807.x. PMID 17381452.