Angiomyolipoma pathophysiology: Difference between revisions
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{{CMG}}''' Associate Editor-In-Chief:''' {{CZ}}, {{Faizan}} | {{CMG}}''' Associate Editor-In-Chief:''' {{CZ}}, {{Faizan}} | ||
==Pathophysiology== | ==Pathophysiology== | ||
Since all three components of an angiomyolipoma (vascular cells, immature smooth muscle cells and fat cells) contain a [[Two-hit hypothesis|"second hit" mutation]], they are believed to have derived from a common [[progenitor cell]] that suffered the common second hit mutation. | Since all three components of an angiomyolipoma (vascular cells, immature smooth muscle cells and fat cells) contain a [[Two-hit hypothesis|"second hit" mutation]], they are believed to have derived from a common [[progenitor cell]] that suffered the common second hit mutation. [[Angiomyolipoma]]s are members of the perivascular epithelioid cells tumour group (PEComas) and are composed of variable amounts of three components; blood vessels (-angio), plump spindle cells (-myo) and adipose tissue (-lipo). Almost all classic angiomyolipomas are benign but they do have the risk of rupture with bleeding or secondary damage/destruction of surrounding structures as they grow. | ||
===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
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[[Image:Renal angiomyolipoma (4) HMB-45 immunostain.JPG|thumb|left|350px|4. Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. The same case as demonstrated in "Image 1". HMB-45 immunostain.]] | [[Image:Renal angiomyolipoma (4) HMB-45 immunostain.JPG|thumb|left|350px|4. Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. The same case as demonstrated in "Image 1". HMB-45 immunostain.]] | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 14:32, 21 September 2015
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Angiomyolipoma Microchapters |
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Diagnosis |
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Angiomyolipoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Angiomyolipoma pathophysiology |
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Risk calculators and risk factors for Angiomyolipoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2], Faizan Sheraz, M.D. [3]
Pathophysiology
Since all three components of an angiomyolipoma (vascular cells, immature smooth muscle cells and fat cells) contain a "second hit" mutation, they are believed to have derived from a common progenitor cell that suffered the common second hit mutation. Angiomyolipomas are members of the perivascular epithelioid cells tumour group (PEComas) and are composed of variable amounts of three components; blood vessels (-angio), plump spindle cells (-myo) and adipose tissue (-lipo). Almost all classic angiomyolipomas are benign but they do have the risk of rupture with bleeding or secondary damage/destruction of surrounding structures as they grow.
Microscopic Pathology
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