Glioma natural history, complications and prognosis: Difference between revisions
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*Tumor is in the [[brain]] or [[spinal cord]] | *Tumor is in the [[brain]] or [[spinal cord]] | ||
*Whether the tumor can be removed by [[surgery]] | *Whether the tumor can be removed by [[surgery]] | ||
*Whether the cancer has just been diagnosed or has recurred. | *Whether the cancer has just been diagnosed or has recurred. | ||
*The patient's general health. | *The patient's general health. | ||
*DNA [[methylation]] of the O6-methylguanine-DNA methyltransferase ([[MGMT]]) gene promoter. | |||
*Mutation of [[isocitrate dehydrogenase]]: IDH1 or [[IDH2]] genes. | |||
*Codeletion of [[chromosomes]] 1p and 19q. | |||
Gliomas are rarely curable. | Gliomas are rarely curable. | ||
Revision as of 15:10, 21 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The prognosis of glioma is poor.
Natural history
Complications
Prognosis
The prognosis for glioma depend on the following:
- Type and grade of the tumor
- Tumor is in the brain or spinal cord
- Whether the tumor can be removed by surgery
- Whether the cancer has just been diagnosed or has recurred.
- The patient's general health.
- DNA methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter.
- Mutation of isocitrate dehydrogenase: IDH1 or IDH2 genes.
- Codeletion of chromosomes 1p and 19q.
Gliomas are rarely curable.
The prognosis for patients with high-grade gliomas is generally poor, and is especially so for older patients. Of 10,000 Americans diagnosed each year with malignant gliomas, about half are alive one year after diagnosis, and 25% after two years.
Those with anaplastic astrocytoma survive about three years.
Glioblastoma multiforme has a worse prognosis with less than a 12-month average survival after diagnosis, though this has extended to 14 months with more recent treatments.[1]
References
- ↑ Rob Stein (May 20, 2008). "Malignant Gliomas Affect About 10,000 Americans Annually". Washington Post.