Glioma natural history, complications and prognosis: Difference between revisions
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*Tumor is in the [[brain]] or [[spinal cord]] | *Tumor is in the [[brain]] or [[spinal cord]] | ||
*Whether the tumor can be removed by [[surgery]] | *Whether the tumor can be removed by [[surgery]] | ||
*Whether the cancer has just been diagnosed or has recurred | *Whether the cancer has just been diagnosed or has recurred | ||
*DNA [[methylation]] of the O6-methylguanine-DNA methyltransferase (''MGMT'') gene promoter | *DNA [[methylation]] of the O6-methylguanine-DNA methyltransferase (''MGMT'') gene promoter | ||
*Mutation of [[isocitrate dehydrogenase]]: IDH1 or [[IDH2]] genes | *Mutation of [[isocitrate dehydrogenase]]: IDH1 or [[IDH2]] genes | ||
*Codeletion of [[chromosomes]] 1p and 19q | *Codeletion of [[chromosomes]] 1p and 19q | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 15:26, 21 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The prognosis of glioma is poor.
Natural history
Complications
Prognosis
The prognosis for glioma varies with the grade of tumor: WHO grade 1 and WHO grade 4 have the most favorable and worst prognosis, respectively. The 1-year and 2-year survival rate of patients with malignant glioma is approximately 50% and 25%, respectively.
The prognosis for glioma may depend on other factors which include:[1]
- Tumor is in the brain or spinal cord
- Whether the tumor can be removed by surgery
- Whether the cancer has just been diagnosed or has recurred
- DNA methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter
- Mutation of isocitrate dehydrogenase: IDH1 or IDH2 genes
- Codeletion of chromosomes 1p and 19q
References
- ↑ Prognostic factors of glioma. National Cancer Institute. http://www.cancer.gov/types/brain/patient/adult-brain-treatment-pdq